Nutraceuticals Flashcards

1
Q

What are Nutraceuticals?

A

Food, or parts of food, that provide medical or health benefits, including the prevention and treatment of disease

Nutraceuticals are dietary supplements that have a bioactive agent, which may have been isolated or presented in a concentrated form, and which may provide health improvement or enhancement.

A phrase that is often linked and confused with nutraceuticals is ‘functional food’. With the latter, the food will have a compound that has a specific medical or health benefit.

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2
Q

Facts about Marketing of Nutraceuticals

A

Marketing of nutraceuticals cannot include medical claims since medicines require a medicine license that can be very expensive and will involve extensive research and time for data to be generated for making the claim. So, many promoters of nutraceuticals prefer to advance their product as a dietary supplement since marketing a nutraceutical involves a fraction of the time and is considerably cheaper.

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3
Q

State the factors that have contributed and continue to contribute to the increasing demand for nutraceuticals:

A

Changes in population demography with % of over 60’s said to increase by 2020.

Reports of scientific studies on both nutraceuticals and functional foods.

 Better education and availability/awareness of information.

Better understanding of the concepts that promote healthy living and increased availability of    health care

Better regulation of food and its sources.

 Availability and accessibility of healthy foods, including in developing countries
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4
Q

State the reasons why consumers want to take nutraceutical supplements

A

just to improve general health,
delay onset of age-related health problems,
recovery after illness, overcome stress,
maybe recommended by a health professional,
support for conditions such as pregnancy, and slimming, and improving sports performance.

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5
Q

State the formulations of nutraceuticals available

A

tablets, capsules, and soft gels.
However, it is interesting to note that suppliers of nutraceuticals are not just improving their product information, but some are promoting their products in formulations that are often associated with medicines e.g. soft chewable, controlled release, oral disintegrating tablets, and oral strip films.

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6
Q

State the variety of Nutraceuticals available

A

melatonin, coenzyme Q10, lycopene, carnitine, lutein, resveratrol, γ-linolenic acid, omega-3 fatty acids, flax seeds, soya isoflavones, tea (green and black), glucosamine, and chondroitin.

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7
Q

Nutraceuticals are obtained from?

A

Most of the nutraceuticals are of either plant or animal origin (e.g. cartinine) and hence can be regarded as natural products.

Only those which are present in the natural source in sufficient quantities and are commercially viable are extracted from these. Methylsulfonylmethane, useful for diseases of painful joints, is obtained by means of chemical synthesis. Some, such as coenzyme Q10, are obtained from fermentation processes. Some nutraceuticals are complex mixtures e.g. soya isoflavones, green tea and omega-3 fatty acids.

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8
Q

Nutraceuticals are obtained from?

A

Most of the nutraceuticals are of either plant or animal origin (e.g. cartinine) and hence can be regarded as natural products.

synthesis

fermentation process

Only those which are present in the natural source in sufficient quantities and are commercially viable are extracted from these.

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9
Q

An example of a nutraceutical useful for diseases of painful joints obtained by means of chemical synthesis is called?

A

Methylsulfonylmethane

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10
Q

An example of Nutraceutical obtained from fermentation processes is called?

A

coenzyme Q10, is obtained from fermentation processes

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11
Q

List examples of Some nutraceuticals that are complex mixtures

A

soya isoflavones, green tea, and omega-3 fatty acids.

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12
Q

Where the origin of nutraceuticals is from synthesis, there needs to be care with production of isomeric forms. true or false and why?

A

true because some of the isomers can be toxic

for example , D-form of carnitine is toxic and the L-form can be preferentially prepared by means of chiral synthesis

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13
Q

State the source of Resveratrol

A

Resveratrol occurs in the skin of red grapes (Vitis vinifera), peanuts, berries such as blueberries and cranberries, and the roots of Japanese knotweed (Polygonum cuspidatum).

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14
Q

Products of grapes, such as red wine and grape juice contain……..

A

resveratrol (and flavonoids) and it can also be produced synthetically.

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15
Q

Resveratrol is a stilbene derivative made up of what type of compound?

A

Polyphenolic compound

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16
Q

Resveratrol can occur as ……..

A

Glycoside

17
Q

Resveratrol-3-O-beta-glucoside is called……

A

Piceid

18
Q

Facts about Resveratrol

A

Its presence was first identified in red wine in 1992 after remarks relating to the “French Paradox” (diet is rich in saturated fat and cigarette smoking, but death from coronary heart disease relatively low.)
However, the contribution resveratrol makes for this protective role is not very clear, but it has been shown in vitro to inhibit the growth of cancer cells in some animal models, and to extend lifespan of yeast, worms, fruit flies, fish, and mice fed a high-calorie diet. The proof of similar effects in humans is not available presently.

19
Q

Pharmacokinetics of Resveratrol

A

Resveratrol is readily absorbed when taken orally, but is metabolized fairly quickly. Plasma concentrations normally peak after an hour.

20
Q

Biological activities are associated with resveratrol

A

Being phenolic, it is expected to have antioxidant properties, useful for scavenging free radicals. Its shape and size, along with the phenolic group is likely to allow it to interact with estrogen receptors. The effect will be weak, and it could act as an agonist or an antagonist.

21
Q

Resveratrol and cancer

A

Resveratrol has been found to inhibit proliferation by inducing cell cycle arrest and then induce apoptosis in a number of cancer cell lines. It has also been shown to minimize cellular toxicity generated by chemotherapeutic drugs. More recently, resveratrol has been revealed to have potential to be a chemo sensitizer for doxorubicin and thus requiring 2.5 times less dose of doxorubicin. In vitro it inhibit angiogenesis, which cancer cells seem to promote.

22
Q

Inflammation is associated with……..

A

cell production, angiogenesis, and inhibition of apoptosis

23
Q

Resveratrol has been shown in vitro to …..

A

Resveratrol has been shown in vitro to inhibit cyclo- and lipo-oxygenases.

24
Q

Atherosclerosis is associated with…..

A

Atherosclerosis is associated with inflammation which leads to myocardial infarction.

25
Q

In cultured endothelial cells, resveratrol inhibits the oxidation of…….

A

of LDL and stimulates formation of nitric oxide (important for arterial relaxation).

26
Q

In vitro studies have shown resveratrol inhibits……

A

inhibits platelet aggregation, which if not controlled can lead to myocardial infarction or stroke

27
Q

Facts about Catechins (green, black, and [oolong] teas)

A

Tea is widely consumed and often broadly described as green and black teas. The latter involves fermentation in its production which results in oxidation of many of the polyphenols. Besides caffeine and theophylline (alkaloids), they also contain a group of compounds called catechins.

28
Q

What are Catechins?

A

Catechins are flavonoid derivatives and hence have phenolic groups. They are the main compounds of interest occurring in teas. There are four closely related isomers of which (—) epigallicatechin gallate (EGCG) is the most abundant

29
Q

What percentage of catechins is composed in green tea?

A

For dry weight of green tea, 30-42% is composed of catechins

30
Q

What percentage of Catechins is composed in black tea?

A

While for dry black tea this is only 3-10%.

31
Q

Green and black tea contains what?

A

Both teas also contain caffeine and related structures

32
Q

How is a green tea produced?

A

Production of green tea involves steaming and heating the leaves of Camellia sinensis which inactivates the enzyme polyphenol oxidase and thus prevents the degradation of catechins

33
Q

How black tea is synthesized?

A

black tea leaves are dried naturally before being crushed which enables polyphenol oxidase to oxidize the catechins

34
Q

The high polarity of the catechins reduces their bioavailability. True/False

A

True