NUTR Midterm Flashcards

1
Q

Energy unit is provided in _____

A

Kilocalories or kilojoules

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2
Q

Difference between sugar and starches
Sugar is the _____ form
Starch is more ____ and many of many sugars liked together

A

Sugar is the simplest form

Starch is more complex and many of many sugars liked together

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3
Q

Carbohydrates provide —- kcal per gram

A

4

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4
Q

What is Fiber

It is a ______ that cannot be _____ and thus provides very little energy

A

It is a carbohydrate that cannot be digested and thus provides very little energy

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5
Q

Where can you find fiber

A

Vegetables fruits legumes and whole grains

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6
Q

Legumes
The ______ seeds of plants, belonging to the ___ family
Includes peas peanuts beans soybeans and ____

A

The starchy seeds of plants, belonging to the peas family

Includes peas peanuts beans soybeans and lentils

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7
Q

Lipids provide—— Kcal per gram
And what are there characteristics
What is the most common one found in the body
And they are_____ and concentrated source of energy
The most abundant source of energy is _____

A

9kcal
And they are lighweight and concentrated source of energy
The most abundant source of energy is triglycerides

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8
Q

Protein function
how many kcal in a gram
Growth and maintains of body structures and regulation of body processes
Proteins in ____ products better match our need than ____

A

Growth and maintains of body structures and regulation of body processes
4
Proteins in animal products better match our need than plants

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9
Q

a study that studies the interactions that occur between living organisms and food.

A

a study that studies the interactions that occur between living organisms and food.
Nutrition

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10
Q

Chemical substances in food that provide energy and structure and help regulate body processes.

A

Chemical substances in food that provide energy and structure and help regulate body processes.
Nutrients

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11
Q

Foods that have been specially treated or changed from their natural state

A

Foods that have been specially treated or changed from their natural state
Processed foods

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12
Q

4 major food groups

A

Vegetables and fruits
Grain products
Milks and alternatives
Meat and alternatives

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13
Q

Does Data show that are not eating as many nutritious vegetables, fruits, milk and alternatives, and grains products as they should.

A

Yes

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14
Q

The only category that was not too low was—-

A

Meat and alternatives

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15
Q

17-18% of adults consume more —- than they should

A

Fat

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16
Q

Nutrients that must be provided in the diet because the body either cannon make them or cannon make them in sufficient quantities to satisfy its needs.

A

Nutrients that must be provided in the diet because the body either cannon make them or cannon make them in sufficient quantities to satisfy its needs.
Essential Nutrients

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17
Q

Foods to which one more more nutrients have been added, typically to replace nutrient losses during processi

A

Fortified Foods;

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18
Q

Category of products regulated by Health Canada that include Vitamin and mineral supplements, amino acids, and mineral supplements….. and herbal remedies… transition medicines,,,, they occupy the middle ground between drugs and food
regulated by Health Canada

A

natural Health Products

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19
Q

Substances found in plant foods that are not essential nutrients but may have health promoting properties

A

Phytochemicals

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20
Q

substances found in animal foods that are not essential nutrients but may have health promoting properties

A

Zoochemicals

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21
Q

What are the 6 classes of nutrients

A
carbohydrates
Lipids 
Proteins 
Water 
Vitamin 
Minerals
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22
Q

What are the energy yielding nutrients

A

Carbohydrates, lipids, ad proteins

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23
Q

Is alcohol a erngy providing nutrient?

A

NO it provides energy but not a nutrients because you do not need it to support life

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24
Q

Macronutrients

Includes ;

A

nutrients needed by the body in large amounts

includes; water protein, lipids, proteins

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25
Q

Micronutrients

Includes: _____

A

nutrients needed in the body in small amounts. Usually mg

includes: vitamins and minerals

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26
Q

Organic molecules

Includes

A

Those containing carbon bonded to hydrogen

Lipids carbs proteins and vitamins

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27
Q

Inorganic molecules

Includes

A

Those containing no carbon hydrogen bond

Minerals and water

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28
Q

_____ Acts as a lubricant, tranport feud and regulator of body temperature

A

Acting as a lubricant, tranport feud and regulator of body temperature

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29
Q

How many vitamins and what is the functions
They are ___ molecules
They regulate body process
They are involved in helping the body use the ___ from carbs, proteins and lipids

A

13
Organic molecules
Regulate body processes
Many are involved in helping the body use the energy from carbs, lipids, and proteins

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30
Q

Important in structure

Bone strength, and transport of oxygen, transmission of nerve impulses

A

Minerals

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31
Q

Minerals and vitamins

Which one is more stable

A

Minerals

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32
Q

When energy is not needed immediateltly, it is mainly stored as ___

A

Fat

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33
Q

Most of the human body is weight is due to ___ and ___ and —-

A

Water protein and fat

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34
Q

What forms the ligaments and tendon and hold the bones together and attach muscles to bone

A

Proteins

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35
Q

The sum of all the chemical reactions that take place in a living organism

A

Metabolim

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36
Q

____ hardens the teeth and bones

A

Minerals

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37
Q

Any condition resulting from an energy or nutrients intake either ablove or below what is optimal

A

Malnutrition

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38
Q

Any condition resulting from an energy or nutrient intake below that which meets nutritional needs

A

Undernutrition

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39
Q

_____ is an excess of nutrients
Is a form of _____
Adverse or toxic reaction may occur

A

Over-nutrition

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40
Q

What are most nutrient toxicity’s due to
Excessive intake of vitamins and mineral ______
Hard to take too much with just food

A

Excessive intake of vitamins and mineral supplements

Hard to take too much with just food

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41
Q

Overnutrition in canada today do not have immediate toxic effects but contribute to the development of ______

A

Chronic disease

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42
Q

Some genes affect your risk of developing chronic disease such as heart disease cancer, high blood pressure and diabetes, but their impact is affected by what you eat
True of false

A

True

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43
Q

The study of how diet effects genes and how individual genetic variation can affect the impact of nutrient or other food components on health

A

Nutritional genomic

Nutrigenomic

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44
Q

What is a healthy diet

A

A diet that proves the right amount of energy to keep weight in the desirable range; the proper amount of carb, proteins, fats, plenty of water and sufficient and not excessive mout of essential vitamins and minerals

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45
Q

A state in which there is a sufficient amout of nutrient or nutrients in the diet to maintain health

A

Adequacy

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46
Q

An evaluation of the nutrient content of food in comparison to the kcalories it provides

A

Nutrient density

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47
Q

To ensure adequacy, a diet must be rich in ——— foods Rich food contain substantial amounts of nutrients per kcalorie

A

Nutrient rich

Rich food contain substantial amounts of nutrients per kcalorie

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48
Q

What is a nutrient rich food

A

Broccoli

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49
Q

True or false

Consuming iron with milk increase absorption

A

False!
Orange juice and iron increases absorption
Milk reduces it

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50
Q

The increase in portion sizes for typical restaurant and snack foods absorbed over the last 40 years

A

The increase in portion sizes for typical restaurant and snack foods absorbed over the last 40 years
Portion distortion

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51
Q

Some of the first nutritional recommendations were made in England when ——

A

The industrial revolution caused a rise in urban populations

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52
Q

What are the two major approves to formulating nutritional recommendations?

A

Nutrient based approach- describes the amounts of individual nutrients that are needed ex. How much vitamin c
Food based approach- a dietary pattern is recommended,. Amounts and types of food to eat to ensure an adequate intake of nutrients

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53
Q

A description of a way of eating that includes the types and amounts of recommended foods and food groups, rather than nutrients
Ex. How many servings of vegetables

A

A description of a way of eating that includes the types and amounts of recommended foods and food groups, rather than nutrients
Ex. How many servings of vegetables

Dietary plan

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54
Q

________ is a set of reference values for the intake of energy, nutrients, and food components that can be sued for planning and assessing the diets of healthy people in the US and Canada
America used to have RDA
Canada used to have RNI
They combined and standardized it

A

Dietary reference intakes A set of reference values for the intake of energy, nutrients, and food components that can be sued for planning and assessing the diets of healthy people in the US and Canada
America used to have RDA
Canada used to have RNI
They combined and standardized it

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55
Q

When was the first food guide in canada developed

A

1942 during the war

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56
Q

What does the ____ do and what is its characteristics
Used to plan diets for healthy people
They also ave values for different staged groups
They also have one for pregnant and lactating women

A

DRI
Used to plan diets for healthy people
They also ave values for different staged groups
They also have one for pregnant and lactating women

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57
Q

DRI (dietary reference intake ) for macronutrients and micronutrients include 4 different sets of reference values
What are they

A

estimated average requirement
Recommended dietary allowance
Adequate intake
Tolerable upper intake level

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58
Q

Uptakes that are sufficient to meet the nutrient needs of almost all healthy people in a specific life stage and gender groups

A

Uptakes that are sufficient to meet the nutrient needs of almost all healthy people in a specific life stage and gender groups
Recommended dietary allowances

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59
Q

Intakes that should be used as a goal where no RDA exists

These values are an approximation of the average nutrient intake that appears to sustain a desired indicator of health

A

Adequate intake

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60
Q

Maximum daily intakes that are unlikely to pose a risk of adverse health effects to almost all individuals in the specified life stage and gender group

A

Tolerable upper intake levels

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61
Q

Intakes that meet the estimated nutrient needs of 50% of the individualist in a fender and life stage group

A

Estimated Average requirements

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62
Q

A functional indicator such as levels of a nutrient in the blood that can be measure to determine the biological effect on a level of nutrient intake

A

Criterion of adequacy

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63
Q

What are the two values of DRI that ca be sued to set foals for individuals intake and can be sued to plan or evaluate individual diet

A

Recommended dietary allowances

Adequate intakes

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64
Q

What DRI is sued to help individuals prevent nutrient toxicities

A

Tolerable upper intake levels

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65
Q

What DRI is used to determine RDA

A

EAR estimated average requirements

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66
Q

typically the activity of the enzyme, how much in the body, in the unkind to examine the biological effect of a level of nutrient intake

A

The criterion of adequacy

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67
Q

How is EAR measured
They do an experiments too see how much a certain molecule is needed to meet ______ . Then examine how much they ate to reach that level. Every person is different so they make a requirement distribution plot (usually normally distributed ) the middle is the ____ % value for EAR

A

They do an experiments too see how much a certain molecule is needed to meet saturation. Then examine how much they ate to reach that level. Every person is different so they make a requirement distribution plot (usually normally distributed ) the middle is the 50% value for EAR

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68
Q

A plot if a nutrient requirements for a group of individuals in the same life stage, typically the plot has the shape of a bell curve

A

Requirement distribution

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69
Q

What % does RDA cover
The recommended dietary allowances covers ___ % of the population
It is the possibility that ___ % of this amount will cover your requirements

A

The recommended dietary allowances covers 98% of the population
It is the possibility that 98% of this amount will cover your requirements

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70
Q

What does it mean if your daily intake is lower than RDA?
It does not mean you are necessarily not take it enough nutrients for you. However the probability of an inadequate intake is increases as it gets lower that RDA

A

It does not mean you are necessarily not take it enough nutrients for you. However the probability of an inadequate intake is lowest is intake equals RDA

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71
Q

What is AI and how is it used
It is used when insufficient experimental data to set an ____ and calculate and ___ .
It means that there must be more research done
Usually based on the ____ nutrient intake by a healthy population, all members are which are meeting nutrient requirements, by an established critic era of adequacy
It is not possible to calculate any _____ of adequacy like EAR

A

It is used when insufficient experimental data to set an EAR and calculate and RDA.
It means that there must be more research done
Usually based on the average nutrient intake by a healthy population, all members are which are meeting nutrient requirements, by an established critic era of adequacy
It is not possible to calculate any probabilities of adequacy like EAR

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72
Q

What is UL and how is it used
____ level os intake that is unlikely to pose a risk of ____ health effects
It is not an ____ amount for everyone
The lowest level of intake that causes the adverse effects is determined and the UL is set ____ enough below this level that even the most sensitive people in the population are unlikely to get affected

A

Tolerable upper intake levels
Max level os intake that is unlikely to pose a risk of adverse health effects
It is not an exact amount for everyone
The lowest level of intake that causes the adverse effects is determined and the UL is set far enough below this level that even the most sensitive people in the population are unlikely to get affected
Usually due to supplements
There is still insufficient data to establish a UL value

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73
Q

A method that indicates the proportion of a population that is not meeting its requirements, indicated by the proportion of the population with intakes below the EAR

A

EAR cut point method

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74
Q

A plot of the intakes of a specific nutrient in a population
50% and below means intake lower than the median

A

intake distribution

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75
Q

How do you establish the proportion of the population that is not meeting its requirement?
Draw an _____ and draw a vertical line equivalent to the ____ . The ___ side of that line is the proportion of the population whose intake is less than the EAR

A

Draw an intake distortion and draw a vertical line equivalent to the EAR. The left side of that line is the proportion of the population whose intake is less than the EAR

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76
Q

Average energy intakes predicated to maintain body weight in healthy individuals
It depends on level of physical activity level too

A

Estimated energy requirements

Average energy intakes predicated to maintain body weight in healthy individuals
It depends on level of physical activity level too

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77
Q

Ranges of intake for energy yielding nutrients, expressed as a percentage of total energy intake, that are associated with reduces risk of chronic disease while providing adequate intakes of essential nutrients

A

Ranges of intake for energy yielding nutrients, expressed as a percentage of total energy intake, that are associated with reduces risk of chronic disease while providing adequate intakes of essential nutrients

Acceptable macronutrient distribution ranges

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78
Q

According to the AMDRs ____ % of kcalories from carbs that you should intake?

A

45-65% of total kcalories

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79
Q

According to the AMDRs ____ % of kcalories that you should get from fat?

A

20-35%

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80
Q

According to the AMDRs what is the % of the kcalories that you should get from proteins?

A

10-35%

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81
Q

What are the 4 food groups in Canada food guide

A

Vetetables and fruits
Grain products
Milks and alternatives
Meant and alternatives

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82
Q

What are the most important nutrients provided by vegetables and fruits
4

A

Vitamin A
folate
Vitamin c
Potassium

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83
Q

What does grain products provide

4 things

A

Fiber
Iron
B vitamins
Magnesium

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84
Q

What does milk and alternatives provide

2 things

A

Calcium and vitamin D

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85
Q

What does meat and alternatives supply

4 things

A

Protein, iron and zinc and some B vitamins

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86
Q

What is the purpose of the Canada’s food guide

A

Reducing the risk of obesity, chronic disease such as type 2 diabetes, heart disease, certain types of cancer, and osteoporosis

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87
Q

What does high sodium intake do to the body

It increases ______ or ______ which increases the possibility of heart disease

A

It increases high blood pressure or hypertension which increases the possibility of heart disease

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88
Q

What colour vegetable does canada food guide recommend and what are they rich in

A

Dark green and orange

They are rich in folate and vitamin a

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89
Q

Canada food guide recommends that —— of the grain products be whole grains

A

Half

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90
Q

What is a good alternative to meets
—- and ___ and ___
They are rich in ___ and ____ which is not found in ___ Protein

A

Lentils beans and tofu

They are rich in folate and fiber which is not found in animal protein

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91
Q

What does fish have a lot of ____

A

Omega 3 fatty acids

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92
Q

How much exercise should we get

A

At least 2.5 hours a week of moderate to vigorous exercise

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93
Q

What percent of the population meets the requirements when following the food guide

A

90

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94
Q

What is the only requirement in the food guide that is not met by the Canada food guide realistically

A

Vitamin d levels of individuals that are over 50

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95
Q

It is a tracker that allows the user to record the food intake
You can write down the food they have eaten and indicate which food group each item is from and compare with recommendated intakes

A

It is a tracker that allows the user to record the food intake
You can write down the food they have eaten and indicate which food group each item is from and compare with recommendated intakes
Food guide tracker

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96
Q


By the dietitians of canada
Provides the public with a wealth of nutritional information
You can analyze the nutrient content of the food that the user recorded on his of her food tracker sheet and get suggestions

A

By the dietitians of canada
Provides the public with a wealth of nutritional information
You can analyze the nutrient content of the food that the user recorded on his of her food tracker sheet and get suggestions

Eattrackers

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97
Q

Pagoda shape for the food guide

A

Korea and china

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98
Q

Mexico, Australia and most European countries use —- shape for the food guide

A

Plate or pie

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99
Q

America has—- groups for their food guide

A

5

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100
Q

Mediterranean diet for the food guide is —— shape

A

Pyramid

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101
Q

What % of the variation of BMI between individuals can be attributed to genes

A

75%

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102
Q

An environment that promotes weight gain by encouraging overeating and physical inactivity

A

An environment that promotes weight gain by encouraging overeating and physical inactivity
Obesogenic environment

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103
Q

Appetite
The desire to consume specific foods that is independent of hunger
Triggered or inhibited by external factors such as sight taste and smell of food, emotions, conversations

A

Appetite

The desire to consume specific foods that is independent of hunger
Triggered or inhibited by external factors such as sight taste and smell of food, emotions, conversations

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104
Q

Why are we getting fat
Availability of ____ food choices
Palatable affordable convenient food is readily available
Accenebility of treats
Portion size____
More single parents, or households with two working parents, meaning less time to prepare meals
Errors in the food guide serving in Canada food guide
Exercising less

A

Availability of tempting food choices
Palatable affordable convenient food is readily available
Accenebility of treats
Portion size increased
More single parents, or households with two working parents, meaning less time to prepare meals
Errors in the food guide serving in Canada food guide
Exercising less

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105
Q

Portion distortion

A

Increase in portion sizes

Because we tend to eat in unites, regardless of size, we naturally increase the amount we eat

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106
Q
We are exercising less.. why? 
Less jobs with \_\_\_\_  labour 
People drive  to work 
More technology 
Televisions, phones 
Less schools programs to save more money and more time for academics.
A
Less jobs with physical labour 
People drive  to work 
More technology 
Televisions, phones 
Less schools programs to save more money and more time for academics.
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107
Q

How many kcalories pre gram in alcohol

A

7

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108
Q

How to calculate % energy from fat

A

—-g x 9 kcalories/g = X kcalories from fat

X / total kcalories x 100 = percent energy from fat

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109
Q

Substances that cannot be broken down into products with different properties

A

Elements

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110
Q

Covers and products the body, help control body temperature

A

Integumentary system

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111
Q

Segregates hormones that regulate processes such as growth, reproductions, and nutrient use

A

Segregates hormones that regulate processes such as growth, reproductions, and nutrient use
Endocrine system

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112
Q

How does the body systems work together for digestion
____ - secrets chemical to help in intake and absorption
_____-aids in digestion by sending nerve signal to control passage of food in digestive tract
____- transport to individual cells
____ , Respiratory and integumentary system allows for elimination for metabolic waste

A

Endocrine- secrets chemical to help in intake and absorption
Nervous system-aids in digestion by sending nerve signal to control passage of food in digestive tract
Cardiovascular- transport to individual cells
Urinary, Respiratory and integumentary system allows for elimination for metabolic waste

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113
Q

The process of breaking food into components small enough be be absorbed into the body

A

The process of breaking food into components small enough be be absorbed into the body
Digestion

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114
Q

The process of taking substances into the interior for the body

A

Absorption

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115
Q

Carbohydrate, protein and fats is converted to —- in digestive system

A

Sugars
Amino acids
Fatty acids

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116
Q

Gastrointestinal tracts is A hollow tube consists in of the mouths pharynx, esophagus, stomachs small intestines large intestine and anus In which ____ and____ of nutrient occurs
_____ -still outside the body

A

A hollow tube consists in of the mouths pharynx, esophagus, stomachs small intestines large intestine and anus
In which digestion and absorption of nutrient occurs
Lumen-still outside the body

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117
Q

Transient time

A

T

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118
Q

_____ The layer of tissue lining the GI tract and other body cavities

Serves as a protective layer and _____

One of the first locations to be affected by ____ deficiency because they need a lot of nutrients

A

Mucosa; The layer of tissue lining the GI tract and other body cavities

Serves as a protective layer and absorption

One of the first locations to be affected by nutrient deficiency because they need a lot of nutrients

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119
Q

Under the _____ is the Connective tissue containing nerves and blood vessels
For support and delivery of nutrients
And signals information to control contraction

A

Connective tissue containing nerves and blood vessels
For support and delivery of nutrients
And signals that control contraction

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120
Q

A vicious fluid secreted by glands in the GI tract and other parts of the body which acts to lubrications, moisten, and protect cells from harsh environments

A

Mucus

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121
Q

Swallows chewed food mixed with saliva

A

Swallows chewed food mixed with saliva

Pharynx

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122
Q

Moves food to the stomach

A

Moves food to the stomach

Esophogus

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123
Q

It churns and mixes food

Secrets acid and a protein digestive enzyme

A

It churns and mixes food
Secrets acid and a protein digestive enzyme

Stomach

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124
Q

Makes bile

Which aids in digestion and absorption of fat

A

Liver

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125
Q

Release bicarbonate to neutralize intestinal contents

Produce enzymes that digest carbohydrate protein and fat

A

Pancreas

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126
Q

Stores bile and releases it into the small intestine when needed

A

Gallbladder

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127
Q

How does nerve signalling work and hormones work in the GI tract

A

When food is in the mouth it can trigger nerve impulse that signals the stomach and prepare itself toe the arrival of food
Can induce muscle contractions

Hormones
Sub aid help prepare different parts of the gut for the arrival of food and thus regulate the digestion of nutrients and the rate at which food ovens through the system

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128
Q

What does saliva do
It moistens the food so it can be easily _______
Behind the enzymic digestion of starch (salivary _____)
Cleanse the mouth and protects teeth from ______
______ the upper GI tract

A

It moistens the food so it can be easily swallowed
Behind the enzymic digestion of starch (salivary Amylase)
Cleanse the mouth and protects teeth from decay
Lubricates the upper GI tract

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129
Q

Lysozyme and where is it found

A

In saliva tears and sweat that is cabable to destroy certain type of bacteria
Helps for teeth decay

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130
Q

A piece of elastic connective tissue at the back of the throat that covers the opening of the passageway to the lungs during swallowing

A

A piece of elastic connective tissue at the back of the throat that covers the opening of the passageway to the lungs during swallowing
Epiglottis

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131
Q

Peristalsis

A

Coordinated muscular contractions that move food through the GI tract
In the esophagus

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132
Q

Sphincter

A

A muscular valve that helps control the flow of materials in the GI tract

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133
Q

Chyme

A

A mixture of partially digestive food and stomach secretions
Except of water, alcohol and drugs … very few absorption here \

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134
Q

Protein digestion

A

Starts in the stomach under pepsin

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135
Q

Nerve and hormones signals originate from the

A

Brain stomach and small intensive
By smell right taste (brain)
Spinach—stimulates the release of gastric secretions and an increase in motility

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136
Q

Pyloric sphincter

A

Helps to regulate the rate at which food empties from the stomach

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137
Q

What type of meal will stay in the stomach the longest

A

High fat

Fat entering the small intestine causes release of hormones that slow GI motility

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138
Q

The —— in the main site of digestion of food and absorption of nutrients

A

Small intestine

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139
Q

A tubular component of the lymphatic system that carries fluid away from the body tissues
Lymph vessels in the intestine are known as lacteral and can transport large particles such as the products of fat digestion

A

Lacteal

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140
Q

What does the pancreas do

A

Secrets pancreases juice which contains both bicarbonate ions and digestive enzymes

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141
Q

Fat digesting enzymes

Breaks triglycerides into fatty acids

A

Lipase

Fat digesting enzymes
Breaks triglycerides into fatty acids

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142
Q

A substance made in the live and sores in the gallbladder

Which is released into the small intestine to aid in the gat digestion and absorption

A

Bile

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143
Q

What is the primary site of absorption of water vitamins minerals

A

Small intestine

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144
Q

What is the primary site of absorption of the products of carbs , protein and fats

A

Small intestine

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145
Q

What is absorbed into the stomach by simple diffusion

A

Fatty acids and vitamin e , water

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146
Q

What is absorbed by facilitated diffusion

A

Fructose

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147
Q

What is absorbed by active transport

A

Glucose

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148
Q

Some absorption of water and vitamins and minerals occur in the colon
T of F

A

True

The micro flora in the body can produce small mouths of fatty acids, vitamin B and Vitamin K which can be absorbed

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149
Q

The system of blood vessels that collects nutrients laden blood from the digestive organs and delivers it to the liver

A

Hepatic portal circulation

The system of blood vessels that collects nutrients laden blood from the digestive organs and delivers it to the liver

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150
Q

What does lymphatic system transport from the digestive tract

A

Fat soluble substances

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151
Q

Where does the water soluble products of fat digestion travel through

A

Absorbed into the capillaries, the hepatic portal circulation
The non soluble part is taken into the laterals which is part of the lymphatic system

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152
Q

Water soluble molecules including amino acids, sugars, water soluble vitamins, and fat go to the —- and then —-

A

capillaries in the hepatic portal system which transports blood directly to liver where absorbed nutrients are processed before they enter the general circulation

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153
Q

What type of substances are go into the lymphatic system

A

Triglycerides, cholesterols and fat soluble vitamins

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154
Q

____ are fat soluble materials such as triglycerides, cholesterol and fat soluble vitamins are incorporated
They go into the ______ , into the lymph vessels and then to the _____ which goes into the bloodstream
And thus do not go past the _____

A

Chylomicrons
Where fat soluble materials such as triglycerides, cholesterol and fat soluble vitamins are incorporated
They go into the lacteals, into the lymph vessels and then to the thoracic dust which goes into the bloodstream
And thus do not go past the Liver

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155
Q

Coenzyme

A

A small organism molecules that is necessary for the proper functioning of many enzymes

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156
Q

Cellular respiration

A

The reactions that break down carbs, fat, proteins in the presence of oxygen to produce CO2, water and ATP

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157
Q

Acetyl co A

A

A metabolic intermediate formed during the breakdown of glucose, fatty acids and amino acids
It is a 2 carbon compound attached to a molecule of coA
Broken down in the citric acid cycle

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158
Q

Excess carbs and protein can be converted to fatty acids for storage
True or false

A

True

It can be stored as body fat

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159
Q

A group of organic molecules most of which do not dissolve in water
They include fatty acids, trigger its and phospholipids and sterols

A

Lipids

A group of organic molecules most of which do not dissolve in water
They include fatty acids, trigger its and phospholipids and sterols

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160
Q

How has the consumption of fat changed over the years

A

It has declined over the last 25 years from 40%-31% and increased a little recently
However many people in the range of 30-50 consume more fat than recommended
Many consume from meal and alternatives and milk and alternatives from pizzas, sandwiches, and baked goods

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161
Q

What types of fat increase the risk of heart disease and cancer

A

Saturated, trans, and cholesterol

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162
Q

Organic molecule made up of a chain of carb do linked to hydrogen atoms with an acid group at one end

A

Fatty acid

Organic molecule made up of a chain of carb do linked to hydrogen atoms with an acid group at one end

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163
Q

Type of lipids with a structure composed of multiple chemical rings

A

Sterols

Type of lipids with a structure composed of multiple chemical rings

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164
Q

Monoglyceride and diglyceride

A

Has one fatty acid with a glycerol

Two fatty acids with a glycerol

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165
Q

What is a structure of a fatty acid
Chain of carbon atoms with an ____ group (___) at the end (acid group)

The other end : ___ and ____ end has a carbon atom attached to a ___ hydrogen atoms (this one is the one does not link to glycerol)

A

Chain of carbon atoms with an acid group (COOOH) at the end (acid group)

The other end : mega and methyl end has a carbon atom attached to a 3 hydrogen atoms (this one is the one does not link to glycerol)

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166
Q

Monosaturated fatty acid and example

A

Has one carbon - carbon double bond
Everything else is saturated

Example: oleic acid

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167
Q

Example of a saturated fatty acid

A

Palmitic acid

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168
Q

Polysaturated fatty acid and example (when 2 ad 3)

A
Linoleic acid (omega 6) for 2
Alpha linolenic acid (omega 3) 3 

Has 2 or more double carbon bonds

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169
Q

What are some properties of fatty acids

Ex, what does a longer chain mean mean?

A

Usually even number of carbon atoms
14-22 is the norm
When the chain is shorter, remains in liquid at colder temperature
Longer the chain, the easier it is to solidify

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170
Q

Palmitic acid

A

It is a saturated fatty acid
16 carbon
In meats

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171
Q

What are example of saturated fats in animals and plants

A

animals: Palmitic acid has 16 carbon, Stearic acid with 18 carbons

Plants: coconut oil palm kernel oil, and plam oil (tropical oil)

They have longer shelf life

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172
Q

What is oleic acid

A

Is is a monounsaturated fatty acid

In olive and Canola oil, beef

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173
Q

What is linoleic acid or omega 6

A

Has 2 double carbon bond so polyunsaturated

In corn, sunflower, and soybean oils

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174
Q

How does more unsaturated bonds affect how easy it is to become solid

A

More unsaturated bond, more easy it is to be liquid, they melt at cooler temperature than saturated fatty acids

175
Q

What are some omega 3 fatty acids

A

Alpha linolenic acid: in vegetable oils
EPA;
DHA; in fish oil

176
Q

What are some omega 6 fatty acids

A

Linoleic acid: corn and sunflower oils

Arachidonic aicd; in meats

177
Q

What does omega 6 and 3 do

A

They reduce the risk of cardiovascular disease as they are important in the process of blood pressure regulation and immune function and blood clotting

178
Q

What is the difference between cis and trans in in terms of melting point

A

They trans fat has a higher melting point

179
Q

Hydrogenation

A

The process whereby hydrogen atoms are added to the carbon carbon double bonds of unsaturated fatty acids, making them more saturated
This enables the product to be against rancid its

180
Q

What does trans fat do

A

They raise blood cholesterol levels and increase the risk of heart diseases

181
Q

True or false

Some transit fats occur naturally in very small amounts in beef and dairy products

A

True
They differ as they include conjugated linoleic acid
This may increase health benefits such as reduce body fat and body weight

182
Q

Characteristics of triglycerol in
red meats
Olive oil
Corn oil

A

It has has long chain (red meat)
Olive oil- monounsaturated
Corn oil-polyunsaturated

183
Q

Emulsifiers

A

Substances that allow water and fat to mix by breaking large fat globulates into smaller ones
Phosphoglericde can do this because they have both hydrophobic and hydrophilic regions

184
Q

Lecithin

A

Phophoglycierise with a choline group
In membrane and used to synthesize acetylcholine, a neurotransmitter
In eggs and soybeans

185
Q

Cholesterol

A

Is it s sterol

It is used in the cell membrane, mylin, and used to synthesize vitamin D , bile, hormones like testosterone and estrogen

186
Q

How is fat digested in the body

A

Mostly digestion in the small intestine due to lipase
(Some triglyceride digestion in the stomach due to lipase in mouth and stomach, especially in infants)
In the small intestine, bile from gallbladder hero’s to break fat into smaller globules. The triglyceride in the globules are then digested by lipase from the pancreases which breaks them down into fatty acids and monoglyerides. These products of digestion, cholesterol, and other fat soluble substances like vitamins mix with bile to from Michelle’s. They diffuse across into the mucosal cells. The bile acids in the micelles are absorbed and returned to the liver.
This is by fat soluble molecules like vitamins depend on the presence of dietary fat.
Once inside the mucosal cell, the long chain fatty acids like cholesterol must undergo further processing

187
Q

Michelles

A

Particles formed in the small intestine when the products of fat digestion are surrounded by bile acids
They facilitate the absorption of fats

188
Q

Lipoproteins

A

Particles contacting a core of triglycerides and cholesterol surrounded by a shell of protein, phospholipids and cholesterol that transport lipids in the blood and lymph
The inside if hydrophobic and the upside is water soluble
They gecko transport hydrophobic molecules from small intestine, and stored or newly synthesized lipids from the liver

189
Q

Post prandial state

A

The time following a meal when nutrients from the meal are being absorbed

190
Q

How does short and medium tran fatty acids get absorbed

A

They are water soluble

They can be transported to the blood and delivered to cells throughout the body

191
Q

How does long chain fatty acids and cholesterol get absorbed

A

They are incorporated in the lipoproteins. Long chain fatty acids and monoglyerides are first assembled into triglycerides by the mucosal cell.
Then triglerycided and cholesterol combine with phospholipids and protein to form a lipoprotein, called chylomicrons. They are transferred into the lymphatic system and enter the blood stream without liver processing

192
Q

Chylomicrons

What are they mostly comprised of

A

Lipoprotein that transport lipids from the mucosal cells of the small intestine and deliver triglycerides to other body cells
Tryglycerides

193
Q

Explain the path of chylomicrons from lymph to blood

A

as they travel the lymph, goes to blood.
Then lipoprotein opiated breaks down the tryglyerides into fatty acids and glycerol , which goes into the cells. Then the chylomicrons remnants travel to the liver where they are disassembled. (Mostly cholesterol and protein now)

194
Q

Lipoprotein lipase

A

An enzyme that breaks don triglycerides into fatty acids and glycerol. Attached to the cell membranes of cells that line the blood vessels.

195
Q

Where is the major lipids producing organ in the body

A

Liver

196
Q

Explain the path from liver after the lipoprotein lipase action

A

After it chylomicrons remnants go into the liver
The remnants are disassembled and triglycerides from the remnants recovered, and some excess protein, carbs and alcohol can turn into triglycerides too. Then triglycerides in the liver are incorporated into lipoprotein particles called very low density lipoproteins (VLDL). The cholesterol from remnants and newly synthesized can go into VLDL too. They go out into the liver

197
Q

Very low density lipoproteins VLDL

what is is made of mostly

A

Lipoproteins assembled by the liver that carry lipids from the liver and deliver triglycerides to body cells.
G triglycerides

198
Q

Explain VLDL action

A

VLDL go out into the liver and deliver triglycerides to the cell. Lipoprotein lipase breaks down the triglycerides again so it can be taken up. Once the triglycerides are taken up, a denser smaller intermediate density lipoprotein (IDL) remains

199
Q

Low density lipoprotein

A

Lipoproteins that transport cholesterol to the cells. Elevated LDL cholesterol increases the risk of heart disease

200
Q

What happens to IDL

A

2/3 go back in to the liver and the rest it transformed into LDL.

201
Q

What does LDL do

What do they have

A

Main part is still triglycerides but very high portion of cholesterol than lipoprotein

They transport cholesterol. They bind to the LDL receptor, and enters the cell. If there is too much in the body, then they can not be taken up. This can results in heart disease
Called bad cholesterol

202
Q

high density lipoproteins
HDL
They have high amout of

A

Lipoproteins that pick up cholesterol from cells and tranport it to the liver so that it can be eliminated from the body. They reduce the risk of heart disease

203
Q

What does HDL do

A

They originated from the intestinal tract and liver and circulate in the blood. They pick up cholesterol from other lipoproteins and body cells. They are temporary storage sites. They can go back to the liver for disposal, or other organs who need i
This is known as good cholesterol because they reduce heart disease risk

204
Q

Most of the lipids in the human body is triglycerides and sores in

A

Adipose tissue

205
Q

Adipose tissue function

A

They help to store energy and changes in temperature and cushion to protect against shock

206
Q

Fat function

A

Mylin
Cell membrane
Lubrication

207
Q

Essential fatty acids

Example

A

Fatty acids that must be consumed in the diet because we cant either make it or enough of it
Linoleic acid (18 carbond omega 6)
Alpha linolenic acid (18 carbons omega 3)
Arachidonic acid (20 carbon omega 6)

208
Q

Alpha linolenic acid

Where can you get it from

A

Walnuts, flaxseeds. Leafy green, canola oil

209
Q

You can make —— by linoleic acid

A

Arachidonic acid

210
Q

Can make —— using alpha linolinic acid

A

DPA and DHA

But usually not enough so eat fish

211
Q

Eicosanoids

A

Regulatory molecules, including prostaglandins and related compounds that can be synthesized from omega 3 and 6 fatty acids
Hormone like structure
Help regulate blood clotting, blood pressure, immune function
The eicosanoids from omega 3 can suppress inflammation but the opposite from the ones made from omega 6
Eat more omega 6

212
Q

Beta oxidation

A

Making fatty acid int o alertly coA

Releases a lot of energy and electron

213
Q

Glycerol can produce ____ and ____

A

ATP and glucose via glucoeogenesis

214
Q

How does the body store excess fat

A

The lipoprotein lipase breaksdwon VLDL and chylomicrons so that they can enter the fat cells

215
Q

How does the body use stored fat

A

Adipose tidier releases free fatty acids into the blood. They get taken up by the liver and converted to VLDL which in turn are secreted by the liver into the blood. Aldo the hormone sensitive lipase, )a enzyme in adipose cells that respond when we have less energy), Promotes breakdown of stored triglycerides. The glycerol and fatty acids are released into the blood, and the body takes them up.

216
Q

What happens when you are fasting and doesn’t have glucose

A

When you don’t have glucose, acetyl co A cant enter the citric acid cycle because no glucose (oxaloacetate). So they are used to make ketones that is a form of energy source .

217
Q

What does insulin do and what happens when there is none

A

It stimulates the uptake of glucose to glucagon and stimulates the activity of lipoprotein lipase.
Liproprotein uptake of triglycerides especially in adipose tissue. If no insulin, many triglycerides are converted to free fatty acids ad goes into the blood stream for energy source

218
Q

Essential fatty acids deficiency

A

A condition characterized by scaly skin and poor growth that results when the diet does not supply sufficient amount of the essential fatty acids
Not enough linolei and alpha linolenic acid

219
Q

Populations that consume a diet high in omega—— fatty acids from fish have a low incidence of heart disease

A

Omega 3 fatty acids
Monounsaturated fat
Grains and vegetables

220
Q

Atherosclerosis

A

A type of cardiovascular disease that involved the buildup of fatty material in the artery wall

221
Q

How can you describe your diet

In two ways

A

In terms of food

Terms of nutrients

222
Q

The canada food guide.. the one in the front of the food arch are… and what are some examples

A
The most important 
Coloured vegetables 
Whole wheat grains 
Skimmed milk 
Legumes
223
Q

What are other food ?

A

High in calories, fat sugar, salt and no nutrients
Example include cakes, chocolate, raspberry jam, coffee, spices
Water

224
Q

Which one the following is an organic compound

Calcium water vitamin c Salt

A

Vitamin c

225
Q

What is folate aka folic acid

A

A vitamin of the B complex
In leafy green vegetables,
In liver and kidney

226
Q

How many serving for adults for vegetables and males

A

7 to 8

8-10 males

227
Q

Grain products serving

A

6-7

8

228
Q

Milk and alternatives serving

A

2

2

229
Q

Meat and alternatives serving

A

2

3

230
Q

Fresh frozen canned vegetables

A

1/2 cup

231
Q

Leafy vegetables

A

Cooked 1/2

Raw 1 cup

232
Q

Fresh frozen canned fruit

A

1/2 cup

233
Q

Orange juice

A

1/2 cup

234
Q

Bread

A

1 slice

235
Q

Bagel

A

1/2

236
Q

Flat bread

A

1/2 pita

1/2 tortilla

237
Q

Cooked rice, bulgur quinoa

A

1/2 cup

238
Q

Cereal

A

3/4 cups

239
Q

Cooked past or courcous

A

1/2 cup

240
Q

Milk

A

1 cup

241
Q

Canned milk evaporated

A

1/2 cup

242
Q

Fortified soy beverage

A

1 cup

243
Q

Yogurt and kefir

A

3/4 cups

244
Q

Cheese

A

1 1/2 oz or 50g

245
Q

Cooked fish shellfish poultry and lean meat

A

1/2 cup

246
Q

Cooked legumes

A

3/4 cup

247
Q

Tofu

A

3/4 cup

248
Q

Eggs

A

2

249
Q

Peanut or nut butters

A

2 TBsp

250
Q

Shelled nuts and seeds

A

1/4 cup

251
Q

American food guide

A

Used to by a pyramid but now a plate

Used to be 5 categories but now 4

252
Q

Medeterrian Heath guide

A

The healthiest guide and pyramid
The base says to be healthy by exercise, and enjoy meals with other people
Based on Crete, Greece and southern Italy
It is PLANT based diet, and fish and sweet food and is the healthiest and less chronic disease risk
Legumes, spices, grains, olive oil
The top of of the pyramid is meats and sweets
Includes alcohol and Drink water

253
Q

Asian diet

A

Pyramid
Be active
Lots of plants
Sake and water and tea

254
Q

Ovovegeterian

Lactoovo

A

Eats eggs

Eats eggs and milk

255
Q

What are the 7 nutrients

A

Fat protein carb vitamin minerals fibre water

256
Q

What does the rainbow graphic visually portray

A

Emphasis on the proportion of the food groups

257
Q

Some cancer is only determined by genes

A

True

10%

258
Q

What is disease mitigation

A

Reducing the risk of the disease
You can do this by eating vegetables
You cant say PREVENT

259
Q

What are some nutrient that are unique to each food group

A

Vitamin c

Calcium

260
Q

All EAR graphs is a normal distribution

A

False

Do not assume

261
Q

What are the essential amino acids

A

Histidine isoleucine leucine lysine methionine, phenylalanine threonine tryptophan valine

All H, L, I, M, V and tryptophan, threonine, and phenylalanine

262
Q

What are the essential nutrients of carbohydrates

A

All

Glucose? All breakdown to glocuse

263
Q

Essential vitamins

A

All the vitamins are essential
Depending on where we live Vitamin d might be an exception
South and north is not enough

264
Q

Essential nutrients for minerals

A

All
Some minerals like lead, cadmium and mercury their function is still not known
Boron, and these minerals function is unknown

265
Q

Is fibre and water essential

A

Yes

266
Q

What are the trends of the nutrient intake throughout the years

A

Proteins hasn’t really changed
Fat went down … recently went up (but the 27% of the fat of the kcalories of fat intake come from other foods ALARMING)
Carbs going up

The total kcal intake has increased more than 200 kcal/day since 1960s.

267
Q

How to calculate BMI

A

BMI= kg/(m2)

268
Q

What are some eating patterns trends

A

A large proportion of population is not earning minimum serving from any of the 4 food guide
-many are getting meats
And the obesity if coming from that other foods section

269
Q

Why is it concerning that we are not getting our nutrients

A

Are main concern is that
Ca Fe Zn folate and fibre

This will take a long term effect on us

Can effect on fertility

270
Q

Precipitous prosperity

A

Many countries are becoming developed and less for making
More processing foods
More Americanized
The worst conditions of obesity is occurring in countries that used to be the poorest

271
Q

All foods groups have fat

A

True

272
Q

Triglyceride What is its structure
Bond
And % in the body

A

3 fatty acids with glycerol with an ester bond

98% of fats we eats are in this form

273
Q

Short chain fatty
Middle chain
Long chain

A

2-4
6-12
14-22

274
Q

What us the fatty acid ends

A

The methyl/omega end

Acid/ carboxyl end

275
Q

Condensation reaction in fats

A

When glycerol and fatty acids stick together

Produces water

276
Q

Palmitic acid

A

16 carbons zero double bond
16:0
In meats and coconut

277
Q

Z:An-B. in fats

A

Z means how many carbons
A how many double carbon bonds
Where the double bond starts

278
Q

Oleic acid omega 0

A

Mounsaturated fatty acid (MUFA)

18: 1n-9
18: 1w-9

Olive oil avocado
Plant based

279
Q

Linoleic acid

A

PUFA
18:2n-6
Any vegetable and seed oil
sunflower and pumpkin seeds

280
Q

In fats double bonds … always —- carbon down the previous one

A

3

281
Q

Alpha linolenic acid

A

18:3n-3
PUFA
In flax seeds and walnuts
Also little do canola oil

282
Q

What does a double mean

A

Greater possibility of oxidation and this is bad

283
Q

EPA eicosapentaenoic acid

A

20: 5n-3

Fish oils

284
Q

DHA docosahexaenoic acid

A

22:6n-3 fish oils

285
Q

What have a lots of monounsaturated

A

Olive oil

286
Q

Saturated

A

Coconut oil

287
Q

Polyunsaturated

A

Sunflower oil

288
Q

Saturated fat increase —- cholesterol

A

LDL cholesterol

289
Q

What are some symptoms of deficiency of essential fat

A

Scaly dermatitis (skin flaky skin, cracked skin )
Impaired growth in children
Excess of water through the skin

290
Q

What are the fat soluble vitamins

A

A D and E and K

291
Q

We release energy by ——- the Triglyceride

A

Oxidizing

292
Q

Eicosanoids

A

Signalling molecules but in close distance
Made from fatty acids
Thromboxane

293
Q

Cholesterol is a precursor for

A

Bile acids in fat digestion and steroid hormones and stress hormones (glucocorticoid)

294
Q

When we hydrogenate we don’t know where trans bond occur

A

True

295
Q

Conjugated linoleic acid

A

Natural trans fat made in the lumen of cows

296
Q

18:2n-6
Vs
18;3n-3

A
Both polyunsaturated facts 
1) omega 6 
Linoeic acid 
Any plant oil , nuts
2) omega 3
Alpha linoleneic acid 
Flaxseeds, walnuts, canola oil
297
Q

Legume vs tree nuts

Peanut walnut pinto beans pecan chickpeas lentils almond, peanut

A

Legume: pinto beans, chickpeas, lentils peanut (nitrogen fixing)

Tree nut; almonds, walnuts pecan

298
Q

Partially hydrogenated are —-

A

Spreadable

299
Q

Trans fat

A

Category of fatty acids found in hydrogenated process

300
Q

Cis bond increases a —-

A

Kink

301
Q

Where are cis bonds found

A

They are found in fish that are in cold waters

302
Q

Minority of transit fat can be found in ——

A

Diary fat made in lumen of cows called conjugated linoleic acid
Not much a worry

303
Q

What are the key words to know that it contains trans fat

A

Hydrogenated vegetable oil, shortening

304
Q

What are some foods found in trans fat

A

Cookies crackers pastry crust, pastry, butter (homogenous), deep fried

305
Q

What does trans fat do to our body

A

Coronary heart disease, they increase LDL levels, and decrease HDL levels

306
Q

Why saturated fats do to our bodies

A

They are linked to increase in LDL levels

307
Q

Hepatic portal system

A

The vessels and vascular system

308
Q

Digestion

And there smallest unit

A

Enzymatic breakdown of food constitutes into the smallest absorbable unit
Needs and enzyme
Glucose fatty acids and animo acids

309
Q

Absorption

A

Transfer of digest food components across absorptive surface of GI track into vascular or lymphatic systems

310
Q

various pathways nutrients take following digest and absorption

Stored or used to make other molecules Depending on the bodies needs

A

Metabolism

311
Q

Where is majority of the fats absorbed

A

Fats

312
Q

Where is the bile acid produces

A

Liver

313
Q

What is the job of bile acid and what is their structure, and how does relate to their job

A

They disperse fats into smaller droplets and this is called emulsification
Try to mix it into water

They have a hydrophobic and hydrophilic areas. And they form a Michelle with the fatty acids and monoglyceride.

The fatty acid, the carboxyl end is outside the Michelle.

314
Q

Lipase

A

They breakdown the triglycerol.
Sometimes however their function is not accurate and will leave monoglycerides,, they tend to leave fatty acid in the middle chain,

315
Q

What happens when the Michelle hits the mucosa layer

A

The Michelle flips, and the hydrophobic portion is attached to the Mucosa layer and gets absorbed.
Depending on the length of the fatty acids
If smaller and exactly 12, then will get into the portal vein (surrounded the intestines)with other water soluble substances to the liver
If lager than 14, (majority), reformation of the TG inside the mucosa cell.
The TG will be packed into the chylomicrons and fat soluble vitamins, and cholesterol. This will be absorbed into the lymphatic.

316
Q

Where does the lymphatic lead to

A

The thoracic duct and goes into the vascular system

317
Q

What happens in the bile acids that get absorbed

A

The bile acids are reabosorbed into the liver and to the gall bladder

318
Q

Enterohepatic circulation

A

The cycle of getting going to the intestines and liver

319
Q

What are the main points of bile acids
What are they made from
What are they used for
And how are they recycled, and how many times a meal, and what happens to those not recycled

A

1)They are made from cholesterol in the liver
2) a.They are used to emulsification (they make it smaller so they can go into water)
2) b. They form Michelle’s
3) amount required each day are much later then the amount synthesized. This is because of the enterohepatic circulation ( Reabsorption recycling) is very efficient…. 3-5 times a meal
That is not recycled will be lost in the fecese

320
Q

Soluble fibre.. where is it found

A

Oat meal, citrus fruits, the inside of the fruits and legumes

321
Q

What happens to people with high blood cholesterol

A

Coronary heart disease.

322
Q

What does soluble fibre do

A

They find to cholesterol and bile acids
This means less cholesterol is absorbed in the body
Less bile acids recycled, meaning the liver has to make bile acids from the cholesterol

323
Q

Cholesterol can be made in the liver to the point where you would not need to consume any

A

True

324
Q

Atherosclerosis

A

A type of cardiovascular disease that involved the buildup of fatty material such as lipids and fibrous material in the artery wall

325
Q

What does the build up of lipids and fibrous material on artery walls do

A

They reduce elasticity and blocks flow

326
Q

Atherosclerotic plaque

What does it consist of

A

The cholesterol rich material that is deposited in the arteries of individuals with atherosclerosis.
Consists of cholesterol, smooth muscle cells, fibrous tissue and eventually calcium
This is the aftermath of the inflammatory response that is initiated by an injury

327
Q

What is the process of development of plaque to its rupture

Plague is the buildup under the cells

A

1) the cause is unknown but can be due to elevated blood levels of LDL cholesterol, glucose, high blood pressure
2) once there is an injury, the lining of the artery becomes more permeable to LDL particles which migrate into the artery wall. Once in the wall, they oxidize and become oxidized LDL cholesterol.
3) this LDL cholesterol triggers the product ion and release of substances that cause immune system cells to stick to the lining of the artery and then migrate into the artery wall
4) once the immune cells are inside the wall, they become marcrophages which have scavenger receptors on their surface that binds to transport oxidized LDL cholesterol into the interior of the cell.
5) once macrophages have LDL cholesterol in their cell, they become foam cells.
6) these foam cells accumulate in the artery wall and burst, depositing cholesterol to form a fatty streak
7) macrophages and foam cells secrete chemicals that continue the inflammatory process and promote growth of the plaque
8) smooth muscle cells migrate in the fatty streak and secrete fibrous proteins and platelets clump together around the plaque. As plaques builds. It causes the artery to narrow
9) a fibrous cap forms over the plaque walling it off from the lumen of the artery. If the inflammation continues, the cap can degrade.
10) if the cap ruptures, exposing the inner core, blood clots form and can completely stop blood flow

328
Q

Why is LDL cholesterol harmful

A

It promotes inflammation, and triggers the production and release of substances that cause immune system cells to stick to the lining of the artery and then to migrate into the artery wall.

329
Q

Substance formed when the cholesterol in the LDL particles is oxidized by reactive oxygen molecules. it is key in the development of atherosclerosis because it contributes to the inflammatory process

A

Oxidized LDL cholesterol

330
Q

Proteins on the surface of macrophages that bind to oxidized LDL cholesterol and allow it to be taken up by the cell

A

Scavenger receptors

331
Q

_____ in HDH levels increase the risk of cardiovascular disease

A

Decrease

332
Q

_____ levels of triglycerides increases the rate of cardiovascular disease

A

Increase

It is a measure of VLDL in circulation

333
Q

Lipoproteins

A

To transport Fat around the body

Cholesterol, triglycerol, phospholipids, protein

334
Q

What is the purpose of the proteins on the lipoprotein

A

They serve as ID cards

Allow to enter and dock on certain locations

335
Q

Chylomicicron is high in

And go into

A

Trygleride rich

Adipose (storage ) and muscle tissue (energy)

336
Q

Chylomicrons after docking becomes…. and do

A

Chylomicrons remnants goes into the liver and breaks them down…

337
Q

VLDL what does it do and where is it made

A

Very dense lipoprotein
TG rich. They drop off the fat produced in the liver to the muscle and adipose tissue… and gets smaller
And becalmed a IDL and then LDL

338
Q

LDL

Function and structure

A

Particles in the blood.
Bad cholesterol
It has a highest proportion of cholesterol. Carries cholesterol to the body tissues.
Once it docks off, it goes back to the liver

339
Q

HDL
Structure
And function

A

Most dense in protein

Picks up excess from the body and returns the liver

340
Q

Reverse cholesterol transport

A

Picking up excess cholesterol from the body and returns it to the body

341
Q

Chylomicrons
Where does it go
And the amount of time it spends in the body

A

Carries fat from GIT via lymphatic to the blood to the liver
But will drop off fat in the adipose tissue and muscle tissue on the way
Only present in the body after eating depending on the amount of fat you eat. (2-10hours). This is why you have to fast before you take a sample of blood

342
Q

VLDL
Function
And final location

A

Made in the liver to carry any fat in the liver or by the liver out to the adipose stores, and by time it becomes LDL.

343
Q

What are the two lipoproteins most rich in fat

A

Number 1 is chylomicrons

Number 2 is VLDL

344
Q

LDL

A

To deliver cholesterol to all body tissues, and return to the body

345
Q

What is the problem with LDL and how does this same problem relate to HDL

A

When the liver is already rich in cholesterol, the liver shuts the doors for LDL. Closes the receptors and thus will remain in the blood.
Therefore the LDL levels will rise in the blood. HDL receptors still remain and thus can accept cholesterol from the HDL

346
Q

HDL

A

Pick up the excess liver in the body tissues and returns the liver

347
Q

What is the total cholesterol

Units

A

LDL + HDL + VLDL
MMmol/L

Mg/dl / 40 = X mmol/l

348
Q

What is the total cholesterol that is seen as a cutting point for high cholesterol

For evert 1 % mg/dl drop in total cholesterol, ___ % drop in the CHD

A

200mg/dl

2

349
Q

Higher in TC, the ____ the risk of heart disease goes up

A

Higher

350
Q

Ischemic stroke

A

Stoke due to oxygen due to blockage in the colloid artery

351
Q

Atherosclerosis is a ,..

A

A slow gradual accumulation of cholesterol rich plaque in the arteries
And causes occlusion

Very gradual
And in young children too!

352
Q

Occlusion

A

Decrease in blood flow

353
Q

Fatty streaks are not found in healthy children

A

Flash

Starting to grow at the age of 8

354
Q

Thrombosis

A

In minutes
A decisive event whereby damage to advanced arterial plaque causes clot formation
Clot=thrombosis like a scab!
Causes heart attack because it stops the blood flow

355
Q

Myocardial infraction

A

Heart attack due to thrombosis

356
Q

How does clotting of the artery works

A

1) years of excess dietary trans and saturated cholesterol. And thus the LDL levels increase (LDL levels increase is essential to next step)
2) LDL will oxidize as by kicking around in the system
3) coronary artery is branched is under high pressure and creates stress proteins in this area. The macrophages see theses stress proteins and get stuck in the artery. And goes between the cells. When they see the oxidized LDL particles, they engulf them And becomes foam cells.

357
Q

Why does diabetes increase the risk of CHD

A

High levels of blood glucose that Conor with this disease cause damage to blood vessels.

358
Q

____ are generally affected decade earlier than when when it comes to heart disease

A

Men

359
Q

What can regular exercise do health wise

A

Decrease risk by promoting the maintain economy of healthy body weight, reducing the risk of diabetes, increasing HDL cholesterol, and reducing blood pressure,

360
Q

Excessive intake of cholesterol increases the risk of CHD

A

True

361
Q

Why does saturated fatty acids increase the rate of CHD

And what happens with unsaturated fats?

A

Because liver production of cholesterol carrying lipoprotein increases and the activity and the activity of LDL receptors in the liver is reduced so that LDL cholesterol can not be removed from the blood.

In unsaturated fats, lipoprotein decreases and the number of LDL receptors increases.

362
Q

What does trans fatty acids do to the body

A

It promotes the synthesis of cholesterol in the liver and thus an increase in LDL cholesterol. And may even lower HDL cholesterol
And may increase inflammation (some research )

363
Q

What happens when you eat polyunsaturated fats?

A

Blood levels of LDL cholesterol decreases

Why? Because they increase the expression of the LDL receptor and promote bile acid synthesis

364
Q

What does EPA and DHA do?

A

They increase fatty acid oxidation in the liver, meaning reducing the fatty acids available for VLDL synthesis and secretion into the blood, and in turn reduces the levels of LDL particles.
Also increases the uptake of VLDL particles by adipose tissue

365
Q

What does eicosanoids deceived from EPA do

A

Reduce blood clotting, which may prevent heart attacks and reduce inflammation

366
Q

Where can you find monounsaturated fats and what do they do

A

Olive oil
Reduces LDL cholesterol without decreasing healthy HDL cholesterol
Also anti oxidants in olive oil make LDL cholesterol less susceptible to oxidation

367
Q

What type of foods decreases the rate of CHD

A

Fibre, antioxidant b vitamins, whole grains, legumes, Phyllium, folic acids

No sugar and Salt

368
Q

What % of cancers are inked to dietary and lifestyle choices

A

30-40%

369
Q

Breast cancer and dietary fat?

A

Intake of omega 3 fatty acids can help

However the link between dietary fat (specific type), or whether that is total fat, unsaturated of saturated fat is weak

370
Q

Colon cancer and fat

A

High in processed meats and red meat has been associated with increase in colon cancer
Saturated fats may be a factor
Omega03 from fish may lower
High in fibre decreases the risk

371
Q

What does research say about dietary fat and obesity

A

Not much research shows that fat content only increases obesity
It is due to total kcalories in both and women
In men, research shows that diet high in fibre reduces the risk of obesity

372
Q

Saturated fats, cholesterol and trans fat should be reduced as much as possible

True of false

A

True

373
Q

We should gain ___ % from linoleic acid

And ____ % energy from alpha

A

5-10

0.6-1.2

374
Q

How much saturated and mg from cholesteraol should we take in a day
2000 kcal die

A

20g

No more than 300 mg

375
Q

What should your plate look like

A

Half vegetables
1/4 grains
1/4 meats

376
Q

True or false

A company can state cholesterol free even if they have high levels of saturated fats

A

False

Saturated fats increase cholesterol levels so can not label this

377
Q

What are the major sources of saturated fats and the only source of cholesterol?

A

Meats and dairy products

378
Q

What ar the fat soluble vitamins

A

A D E and k

Beta carotene

379
Q

How does obesity increase the risk of CHD

A

Obesity increases the risk of cardiovascular disease by altering the levels of lipoproteins that circulate in the blood. The greater the adipose tissue mass, more release of free fatty acids. These fatty cids are taken up by the liver where they are synthesized into triglycerides which are packaged into VLDL in the blood. These elevated VLDL alter lipoprotein transport in a way that promotes the development of atherosclerosis

380
Q

When VLDL particle is broken sown by lipoprotein lipase, cholesterol is also released and taken up by _______ for transport to the ______

A

HDL liver

381
Q

What happens when VLDL levels are high because you are obese

A

More uptake of TG by tissue, and cholesterol transfer to HDL, and conversion of the VLDL particle to LDL. However this part it normal

When very high … unusual stuff happens.
Cholesterol from the HDL particle rather than getting taken up by the liver is transferred back to the VLDL particles. This results in a cholesterol depleted HDL particle, which tend to be rapidly cleared from the blood, lowering HDL cholesterol levels, with more VLDL-TG. Then these guys give TG to LDL, making LDL-TG. These guys instead of going to the liver, goes to the interacts with an enzyme called hepatic lipase. To remove the triglycerides, leaving in the blood an LDL particles that is smaller in size than the original LDL particles and enriched in cholesterol. This is called small dense LDL
Small dense LDL are more easily oxidized and they get trapped in the blood vessel.

382
Q

Facts on childhood obesity

A

Screen time
Proportion and advertisements from fast food meals have been growing television promotes snacking behaviour
Less exercise
Kids should not restrict calories but rather create an healthy eating habit environment and promote nutritious meals

383
Q

What does anti oxidants do

A

They are found predominantly found in plants and protect tissues from oxidation

383
Q

What happens when the monolayer breaks in the shoulders And why does it happen

A

Mechanical injury-sudden increase in blood pressure due to unaccustomed exercise
Chemical injury- carbon monoxide, CO, a chemical seen in smocking, chemical breakage, it breaks down tissue

And breaks the monolayer, the platelets sees the damage, and creates the scab and stick to site of adhesion and aggregation and creates a thrombosis. This can cause complete occlusion

384
Q

Myocardial infarction

A

Heart attack

385
Q

Hemorrhagic stroke

A

Brain vessel bust

Not the typical type of stroke

386
Q

Ischemic stoke

A

The carotid artery block that goes to the brain
No oxygen
Some process as CHD and causes as CHD

387
Q

How should we reduce the rate of oxidation

A

Vegetables and fruits have antioxidants

You can eat this

388
Q

If not taken by the liver because it already has enough ___ and ___ , LDL levels because high and gets____ and gets taken up be ____ and leads to Foam cells.

A

Cholesterol and saturated fats
Oxidized
Macrophages

389
Q

HDL is involved in _____ transport
Higher blood HDL is associated with more _____ removal from the tissues
Liver can deal with excess cholesterol

A

Reverse cholesterol

Cholesterol

390
Q

For every ____ pounds of weight loss HDL ____mg/dl increase in HDL
For Every _____ mg/dl increase in HDL CHD reduces by ____ %

A

10 , 2

1, 2-3%

391
Q

How can we increase HDL?
Avoid ____ supplements
Loose weight _____ you are overweight
Quick ______ ,
Exercise _______ exercise
Limit the _______ carbohydrate, and sugar (white flour )
Alcohol intake however it also increases ____ levels

A
Avoid supplementary supplements 
Loose weight IF you are overweight 
Quick smoking,
Exercise aerobic exercise 
Limit the refined carbohydrate, and sugar (white flour )
Alcohol but it also increases TG
392
Q

What does elevated TG means increase lipoprotein increase in ___ and ___ . This means we are taking too much fat or extra fat and carbs or eating all the time.

A

Chylomicrons and VLDL

393
Q

What does saturated fats influence total fat, blood LDL, blood HDL,

A

Increase in total fat (LDL HDL VLDL)
Increases blood LDL
Increase in HDL (and no effect )
Found in cream, fatty meats, unskimmed diary fats

394
Q

How does PUFA influence total fat, blood LDL, blood HDL,

A

Decrease total fat
Decrease blood LDL
Decrease blood HDL

395
Q

How does MUFA influence total fat, blood LDL, blood HDL,

A
Decrease total fat
Decrease blood LDL 
No influence in blood HDL 
Oleic acid olive oils Canola oil 
Best option
396
Q

How does TFAT influence total fat, blood LDL, blood HDL,

A

Increase total fat
Increase LDL
Decrease HDL

397
Q

Anti-oxidants are not found to beneficial in ____

A

Supplements

398
Q

Oxidation is a ___ in oxidation

A

Loss

399
Q

Free radical has an ____ electron and is unstable

Oxidation of a molecule may create a ____

A

Has an unpaired electron and this unstable

Free radical

400
Q

___ are susceptible to oxidation

When it gets oxidized, it gets ____

A

Double bond

Oxidized

401
Q

An oxidized molecule can disrupt_____ other molecules

A

Many

402
Q

_______ is the breakdown product of oxidized fat

A

Malondaldeyhyde

403
Q

The ___ in the LDL gets oxidized

A

TG

404
Q

____ are rich in antioxidants, and not found in _____.

A

Vitamin c, e, b carotene and se

Supplements

405
Q

How does cancer begins?
1)_______ ;… caused by DNA damage … DNA damage caused by ____ , UV, _______ (_____; charcoal due to high temperature cooking of fat), retrovirus

A

initiation ;… caused by DNA damage … DNA damage caused by free radicals , UV, polycyclic aromatic hydrocarbons (PAH, charcoal due to high temperature cooking of fat)

406
Q

What happens when the cell is damaged?
It goes through ______: suicide
Or
It can repair itself if the damage it not too bad.

A

What happens when the cell is damaged?
It goes through apoptosis: suicide
Or
It can repair itself if the damage it not too bad.

407
Q

2nd step in cancer
______: replication of the damaged or mutated cell.
What causes this?
________ ; breakdown of oxidized fats. This means that this promotes cancer but does not initiate cancer
At this stage the tumour may be ______ as it has not spread yet

A
2nd step in cancer 
Promotion: replication of the damaged or mutated cell. 
What causes this? 
Malondiladehyde
Beign
408
Q

3rd stage of cancer
_______ : cancer cells loose the ability to loose contact. And creates a a give mass. At this stage, it accumulates more DNA mutation and spread. When they find a blood source and spread to other tissues, this causes _______.

A

3rd stage of cancer
Promotion: cancer cells loose the ability to loose contact. And creates a a give mass. At this stage, it accumulates more DNA mutation and spread. When they find a blood source and spread to other tissues, this causes metastasis

409
Q

Free radicals can damage us by
DNA damage and cause ____ in cancer development
PUFA
1) LDL to ox-LDL
2) body cell membrane into oxidized ____ that may be a ____ in cancer development
________
-it can oxidize the protein in the lens of the eye and cause ______

A

DNA damage and cause initiation
PUFA
1) LDL to ox-LDL
2) body cell membrane into oxidized PUFA that may be a promoter in cancer development
Protein
-it can oxidize the protein in the lens of the eye and cause cataracts

410
Q

What is dietary cholesterol

1) Is a structural component of all______ cell membrane
2) they are precursor for bile acids and _____ hormones, _____ , vitamin ____ ,
3) present only in the foods of ____ origin
4) it is not an _____ nutrient because the body makes enough cholesterol for the bodies needs
5) cholesterol consumption should be as low as possible but recently to reasonable consumption

A

What is dietary cholesterol

1) Is a structural component of all animal cell membrane
2) they are precursor for bile acids and steroid hormones, eicosonoids, vitamin D,
3) present only in the foods of animal origin
4) it is not an essential nutrient because the body makes enough cholesterol for the bodies needs
5) cholesterol consumption should be as low as possible but recently to resonance consumption

411
Q

___ has extremely high cholesterol but the cholesterol is only in the yolk

A

Egg

412
Q

18:1N-9

A

Oleic acid

413
Q

Cholesterol in egg is found in ____

A

Yolk’

414
Q

dietary cholesterol is not the predominent factor in ___ cholesterol

A

Blood

415
Q

_____ fats with the cholesterol influence the ___- cholesterol levels

A

Saturated

Blood

416
Q

How to influence total serum cholesterol in order of effectiveness

1) reduce ____ and trans fat
2) increase the ____ fibre intake by citrus, legumes, oats, _____ (which contains insoluble and soluble fibre)
3) decease the _____ cholesterol

A

How to influence total serum cholesterol in order of effectiveness

1) reduce saturated and trans fat
2) increase the soluble fibre intake by citrus, legumes, oats, psyllium (which contains insoluble and soluble fibre)
3) decease the dietary cholesterol

417
Q

20;5n-3

A

EPA

418
Q

22;6n-3

A

DHA

419
Q

DHA and EPA both originate from _____ which converts the light energy to this molecules.
Where did they originate?
They discovered that the _____ Inuit have 2 times bleeding than mainland Danes.
And discovered that intake of fish and marine
They also had a low rate of _____

A

DHA and EPA both originate from phytoplankton which converts the light energy to this molecules.
Where did they originate?
They discovered that the Greenland Inuit have 2 times bleeding than mainland Danes.
And discovered that intake of fish and marine and had a low rate of CHD

420
Q

The Greenland Inuits had a lower rate of_______

They did have ascholoterosis

A

The Greenland Inuits had a lower rate of thrombosis

They did have ascholoterosis

421
Q

What type of fish can you find EPA and DHA

A

Salmon mackerel herring sardines (highest)

Cod and sole (low fat )

422
Q

What ate the benefits of EPA?

1) fish oils do not decrease serum _____.
2) decrease the serum _____, which are more enriched in ____ and ____.
3) reduce the decrease platelets. The membrane in the platelet will have fatty acids. When the platelet encourers the site of damage. If the cels has ____ (omega 6), it will tern into eicosanoids (______ ) which stimulates platelets aggregation as well as a vasoconstrictor. When they go to EPA it becomes_____, which has 1/20th of the aggravation potential as thromboxane A2

A

What ate the benefits of EPA?

1) fish oils do not decrease serum cholesterol
2) decrease the serum TG, which are more enriched in chylomicrons and VLDL.
3) reduce the decrease platelets reactivity. The membrane in the platelet will have fatty acids . When the platelet encourers the site of damage. If the cels has linonelic acid, it will tern into eicosanoids (thromboxane A2) which stimulates platelets aggregation as well as a vasoconstrictor. When they go to EPA it becomes txA3, which has 1/20th of the aggravation potential as thromboxane A2

423
Q

What is the ratio of omega 3 to omega 6

A

1-4, 1-10
Currently 1-17
We should not have more omega 3

424
Q

Where DHA found?

In the ___ and ____ and ____

A

Where DHA found?

In the heart, retinal and brain

425
Q

Omega 6 (linoleic acid) ——→ __ (20:4n-6) and eicosanoids

This can protmot inflammation, promote blood clotting and many other things

A

Omega 6 (linoleic acid) ——→ arachidonic acid (20:4n-6)

This can protmot inflammation, promote blood clotting and many other things

426
Q

Omega 3 ——→can become___ 20:5n-3 ーーー→ ____ 22;6n-3

EPA can; _____ inflammation suppress blood clotting, platelet activity

DHA- normal ____ development

The first conversion rate is ___ %
The second conversation is ___ %

A

Omega 3 ——→can become EPA 20:5n-3 ーーー→ DHA 22;6n-3

EPA can; suprress inflammation suppress blood clotting, platelet activity

DHA- normal brain development

The first conversion rate is 5-10%
The second conversation is 2-5%

427
Q

What if do not like fish?

1) try regular plain cod and haddock
2) supplements are pure oils and high in ___ , and can contain ____ such as PCB and dioxins. Also these oils have ____ bonds meaning susceptible to oxidation, and thus contain _____
3) can increase high dose can increase bleeding, ______ stoke, suppress ____ system and if you are _____ increases the glucose levels.
4) you you can have 18:3n-3 can be obtained from walnuts flax seeds, canola oil and whole-wheat. Microalgae seaweed and eggs with DHA.

A

What if do not like fish?

1) try regular plain cod and haddock
2) supplements are pure oils and high in calories, and can contain contaminant such as PCB and dioxins. Also these oils have soluble bonds meaning susceptible to oxidation, and thus contain malondialdehyde
3) can increase high dose can increase bleeding, hemorrhagic stoke, suppress immune system and if you are diabetics increases the glucose levels.
4) you you can have 18:3n-3 can be obtained from walnuts flax seeds, canola oil and whole-wheat. Microalgae seaweed and eggs with DHA.

428
Q

A linolenic acids are found in flaxseeds.
Recommendations:
Have oily fish ____ a week with foods with plant oils.
If you have had a heart attack, you can eat supplements under a physician.
Tuna is low in fats

A

A linolenic acids are found in flaxseeds.
Recommendations:
Have oily fish twice a week with foods with plant oils.
If you have had a heart attack, you can eat supplements under a physician.
Tuna is low in fats

429
Q

Contaminants in fish
Enjoy a ____ and then you can reduce the amounts of risk of contaminants. Avoid ____ of the food chain fish that include shark, ____ tuna, ____ , and marlin.
Good foods include _____, salmon, tilapia

A

Contaminants in fish
Enjoy a variety and then you can reduce the amounts of risk of contaminants. Avoid top of the food chain fish that include shark, albacore tuna, swordfish, and marlin.
Good foods include mackerel salmon tilapia

430
Q

Cancer risks for men and women
Men_- prostate ___ and lug
Women - ___ , lung and ____

A

Cancer risks for men and women
Men_- prostate colorectal and lug
Women - breast lung and colorectal

431
Q

Dietary fat and cancer
What we do not know
1) overall mechanism of fat and cancer are hard to prove
2) difficult to separate fat kcal intake from to_____ kcal. Total Kcal intake is involved in ____
3) what is the type of fat that causes cancer? - hard to know

What do we know

1) accounts for __ - ____% of all cancers
2) high ____ is very protective for cancer
3) high intake of plant food is good, especially ____ vegetables that include surfer. This includes broccoli, kale, cabbages. In fruits, __ fruits and ___ fruits.

Lifestyle

1) lifestyle- __ - ____%
2) be active
3) maintain healthy body weight
4) exposer to hazardous materials

A

Dietary fat and cancer
What we do not know
1) overall mechanism of fat and cancer are hard to prove
2) difficult to separate fat kcal intake from total kcal
Kcal intake is involved in cancer
3) what is the type of fat that causes cancer? - hard to know

What do we know

1) accounts for 30-40% of all cancers
2) high fibre is very protective for cancer
3) high intake of plant food is good, especially cruciferous vegetables that include surfer. This includes broccoli, kale, cabbages. In fruits, coloured fruits and citrus fruits.

Lifestyle

1) lifestyle- 40-50%
2) be active
3) maintain healthy body weight
4) exposer to hazardous materials

432
Q

Fat DRI intake recommendations
Total fat: __% Previously (less then 30)
Saturated: less than ___%…. previously (less than 10)
Trans: ____ as possible/….. previously not mentioned
MUFA; _____ …… same
A-linolenic and linoleic : not prove in humans to be bad. But now it says to have _;___ or 1:__ ratio (more omega 6) … previously less than 10%

A

Fat DRI intake recommendations
Total fat: 20-35% Previously (less then 30)
Saturated: less than 7%…. previously (less than 10)
Trans: low as possible/….. previously not mentioned
MUFA; majority …… same
A-linolenic and linoleic : not prove in humans to be bad. But now it says to have 1:10 or 1:4ratio (more omega 6) … previously less than 10%