Nursing 2005: Intro to Pathophysiology Flashcards
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“Physio”
Study of specific characteristics
“Patho”
- suffering/disease
- The study of the body
Pathophysiology
- disorders or breakdown of body function
- mechanisms of disease
Disease
- disruption of homeostasis (balance and body regulation)
- function is affected depending on:
Ex: age, health, genetic background
Epidemiology
Study of cause and distribution of disease in a population
What are the 2 types of epidemiology?
- Mortality
2. Mobility
Mortality
Disease related death
Mobility
Disease occurrence
What are the 2 types of morbitity?
- Incidence
2. Prevelance
Incidence
Rate or number of disease
Prevalence
Total number of diseases
What are the factors of disease?
- Age
Ex: newborns and elderly - Ethnicity
Ex: ethnicity related diseases
- cystic fibrosis = white people - Gender
Ex: men = prostate cancer vs women = breast cancer - Socioeconomic factors and lifestyles
- socio eco ex: poverty, malnutrition, sanitation, water quality, quantity
- Lifestyle ex: diet, exercise, smoke, alcohol - Geographic location
Ex: Africa = malaria
Humid areas in south = fungal infections
Framework for patho
- Etiology
- Pthogenesis
- Clinical manifestations
- Treatment
- Etiology
Cause/reaction of disease
Classifications of etiology:
A. Inherited
Altered of a gene mutation
B. congenital
Present at birth d/t prenatal influence
Ex: virus, chemicals
C. Infectious
D/t microorganism
D. Degenerative
Loss of structure or body function
Ex: joint disorder
E. neoplastic
- tumor
- cancer
- malignant/benign
F. Immunological
Abnormal immune response
Ex: allergies d/t over sensitivity
Lupus, renal
G. Metabolic
- enzyme deficiency
- diabetes
H. Nutritional
- deficiency
- decrease RBC, folic acid
- r/t diet
I. Psychogenic
Emotional state
Ex: stress = decreased immune system, ulcer
J. Iatrogenic
- Treatment causes health conditions
- surgery, invasive procedures
Ex: chemo = decreased immune response
K. Idiopathic
Unknown
Ex: hypertension = no known cause, could be a combination
- Pathogensis
- occurrence of body after exposure = symptoms
- development of disease
- factor of pathogenesis
Factors of pathogenesis
- Time
- how long pt had disease - Amount/quantity
- how much - Location
- what part of body d/t conditions can vary - Morphological changes
- changes in structure and function of cell depending where it is
- Clinical manifestations
A. Symptoms
Subjective feelings of the disease by the pt
Ex: nausea, fatigue
B. signs
Objective
- things you see
Ex: increased temp, vomit
C. Syndrome
- collection of different s/s that occur for specific disease
- vary d/t stage and nature of disease
Stages of disease
- Latent period
- NO s/s
* - interval of exposure can be short/long depending on the disease
- Incubation period
Infection
*- can be long/short term
- Prodomal period
- 1st s/s of disease
- very vague
- not all have this period
Ex: headache
- Subclincal stage
Pt has disease but NO s/s
Ex: kidney disease
- Acute phase
Disease reaches full intensity
- Convalescence
S/s of recover
- Exacerbation
Sudden increase of s/s or severity
- Remission
- Decrease of disease
- if permanent = cure
Nature of disease
- Acute
- Severe manifestations
- Short
- Treatable
Ex: cold
- Chronic
- last >6 months - lifetime
- s/s vary daily
- goal is to manage symptoms
Ex. Diabetes, cancer, hypertension
Implications for treatment: levels of prevention
- Primary
Prevent altering exposure and susceptibility
Ex: safe sex
- Secondary
Early detection
Ex: physical exam, self breast examination
- Tertiary
Medics, interventions for advanced disease
Ex: radiation, physical therapy, surgery