nuero Flashcards
CJD Clinical presentation
Rapidly progressing
1-Cognitive decline
2- myoclonus
3-ataxia
4- pysch behavioral changes
CJD Tests
MRI- IOC- hyperintense cortex and basal ganglia
LP- 14-3-3 protein
EEG- periodic sharp wave complexes
Variant CJD
avg age 26
Psych symp
painful sensory symptoms
Clinical scenario
BG of ca - with any of headache, sciatica, Cauda eq, multiple cranial nerve palsy, polyradiculonueropathy
Carcinomatuous meningitis
Dx=tumor cells in csf using cytopin( multiple attempts needed for Dx)
CS-
Sudden severe occipital headache, h/o neck trauma, ipsi facial numbness, ispi cerebellar signs, contra pian and temp
Dx- vertrbral artery disection
SAH with BP> 160/110 tx
iv- labetalol(DOC), nicardipine, clevidipneor enalapril
Hypokalemic periodic paralysis tx
K+, acetazolamide, k sparing diuretics
Refer ms tx different stages in pastest
ALS vs Prog bulbar palsy
ALS- both UMN and LMN fts with ul>ll
tx- riluzone
PBP- initially and mainly bulbar ft, later may progress to ALS
Parkinsonism plus + autonomic plus cerbellar
Muliple system atrophy
Refer oxfordshire community stroke subclassification
CS- meningitis, encephalitis, multiple cranial nerve palsy, with history of camping and fever
Nuero borreeliosis
Stiff person syndrome
stiff spasm of proximal ll and lumbar paraspinals
No weakness of ms
No trismus - d/f tetanus
cs- Overweight female/pregnant with headache, papiloedema, vision defect/ greying out of vision
Idiopathic intra cranial hypertension
CN 6 palsy d/t ICH
Always do ct head and venography to r/o SOL and CVT- so that LP can be done for IICH
Fever headache confusion seizure without neck stiffness
Dx- Viral encephalitis
MC- HSV
Tx- iv acyclovir
Neck pain with hemiparesis cn palsy and horners with bg trauma
Internal Carotid disection
Myotonic dystrophy features
Progressive muscle weakness tightness and ms wasting
Worser in cold
AD - Genetics
with CVS ds, cataract , infertility, balding in men
Read dermatomes of lower limb
CS- proximal muscle weakness , tender ms, hypo reflexia with BG - scc lung
Dx- Eaton Lambert Myasthenic syndrome
Ab- pre synaptic voltage gated Ca channel
SCD causes and clinical ft
Causes- B12> Vit E, Fedrichs ataxia
Ft- B/L Spastic paraparesis, Loss of vibration , proprio and touch
Friedrichs ataxia ftr
Gait ataxia +b/l pes cavus+/- kyphoscoliosis
Cerbellar ataxia- dysarthria, nystagmus
optic atrophy, spastic parperesis
extensor plantr
Widespread t inv ECG
Locked in syndrome
Terittory - basilar artery
Quadriplegia, unable to smile/ frown conscious plus upward gaze
Cortico basilar degenaration fts
Symptoms initially u/l then b/l bradykinesia, rigidity
Myoclonus apraxia dystonia
Alien limb phenomenon
