Nucleus, Endomembrane (Lectrure 4) Flashcards
What is the nucleus made up of ( components)
- Nuclear pore complex
- Nuclear envelope
- Chromatin
- Nucleolus
What is the nuclear envelope?
The double membrane surrounding the nucleus
What are nuclear pores?
Nuclear pores and their associated nuclear pore complex determines what goes in and out of the nucleus
What is chromatin?
DNA + associated proteins
What is the nucleolus?
The site of ribosomal subunit assembly
What is nucleoplasm?
The “cytoplasm”of the nucleus
Endomembrane system and membrane trafficking (7 we went over class) AND major themes?
- Nuclear envelope
- Endoplasmic reticulum (ER)
- Golgi
- Vesicles
- Lysosomes
- Vacuoles
- Plasma membrane
Major themes:
- Surface area
- Compartmentalization
- They are highly interdependent
What makes the nuclear envelope an extension of the ER?
- Nuclear envelope is a specialized form of the ER
- The two remain connected because of cell division
- Following anaphase, the nuclear envelope is re-assembled around daughter nuclei
What do vesicles do regarding Endomembrane compartments?
Vesicles transport stuff between endomembrane compartments
About fusion of vesicles with target membrane?
- vesicle contents released
- vesicle membrane incorporated into target membrane
- vesicle membrane proteins incorporated into target membrane
What is the best example of the assembly line concept?
Exocytosis
Vesicles more from:
ER -> golgi -> plasma membrane
What are neurotransmitters an example of?
Exocytosis
What is an example of endocytosis?
Covid-19
What is the endoplasmic reticulum (ER) made up of?
- Rough ER - protein folding and modification
- Smooth ER - lipid synthesis, detoxification
Rough ER vs Smooth ER
Rough ER
- studded with ribosomes
- flattened cisterae
Smooth ER
- no ribosomes
- tubular cisternae
