Nucleotide Synrhesis Drugs

Question 1

Methotrexate

Answer 1

a folic acid analog
an an’-tumor drug inhibits Dihydrofolate reductase, no DHF THF, no dTMP

Question 2

Trimethoprim

Answer 2

Same as above but works on prokaryo’c Dihydrofolate reductase

Question 3

Sulfonamides

Answer 3

a structural analogs of Para-aminobenzoic acid (PABA) an an’bio’c, compe’‘ve inhibit of bacterial produc’on of folic acid

Question 4

6-Mercaptopurine

Answer 4

a purine analog
inhibit PRPP Amidotransferase, the commiFed step for Purine synthesis

Question 5

hydroxyurea

Answer 5

an an’-tumor drug that inhibits Ribonucleo’de reductase blocks Ribonucleo’des conversion into deoxyribonucleo’des

Question 6

5-fluorouracil

Answer 6

an’tumor drug
inhibits thymidylate synthase, no methyla’on of dUMP, no dTMP

Question 7

Folate (Folic acid)

Answer 7

Its deriva’ves are used as carbon donors, methyl-groups

Question 8

Nucleo’de Salvage and Excre’on Enzymes

Answer 8

Las mas k vienen

Question 9

adenosine deaminase

Answer 9

AMP catabolism,
enzyme deficiency, affects T- and B-cells, severe combined immunodeficiency disease (SCID) treatments: Sterile bubble, bone marrow transplant, landmark treatment w/ gene therapy

Question 10

Xanthine oxidase

Answer 10

converts purine excre’on pathway intermediate (xanthine) to uric acid uric acid overproducers experience hyperuricemia Gout, xanthine uric acid treat with Allopurinol to inhibit Xanthine Oxidase
Know the symptoms

Question 11

hypoxanthine-guanine phosphoribosyltransferase (HGPRT)

Answer 11

a slight deficiency could cause Purine deficiencies
a severe deficiency forces salvage Purines (normally 90%) to be excreted (normally 10%) 100% excre’on as uric acid accumulates drama’cally causes Lesch-Nyhan Syndrome Know the symptoms