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Cell and Molecular Biology > Nucleotide biosynthesis > Flashcards

Nucleotide biosynthesis Flashcards

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1
Q

Drugs that affect formytetrahydrofolate (hint: Too Much Stuff)

A

Sulfanomides (PABA analogs)

Methotrexate (folate analog - mammalian)

Trimethropin (folate analog - bacterial)

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2
Q

Mechanism of sulfanomides

A
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3
Q

Mechanism of methotrexate

A
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4
Q

Mechanism of trimethoprim

A
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5
Q

Role of mycophenolic acid in IMP conversion to GMP and AMP

A

Inhibits IMP dehydrogenase

Used to prevent graft/transplant rejection due to proliferating B + T cells

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6
Q

Role of allopurinol in gout

A
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7
Q

Lesch-Nyhan disease

A
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8
Q

Outline the process of generating CTP and dTMP from UMP

A
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9
Q

Differences between pyrimidine and purine biosynthesis

A
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10
Q

Role of 5 fluorouracil in dTMP formation

A
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11
Q

Role of methotrexate on dTMP formation

A
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Cell and Molecular Biology (7 decks)

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