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CHEM231 > Nucleophilic Substitution Reactions > Flashcards

Nucleophilic Substitution Reactions Flashcards

1
Q

Good Leaving Groups

A

OTf
OTs
OMs
I
Br
Cl

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2
Q

Bad Leaving Groups

A

F
SR
OH
OR
NH2

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3
Q

Nu ^-

A

Strong nucleophile, strong base

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4
Q

Nu :

A

Weak Nucleophile, weak base

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5
Q

Polar protic solvents

A

H2O, MeOH, EtOH, tBuOH, acetic acid (CH3CO2H)

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6
Q

Polar aprotic solvents

A

acetone, DMSO, DMF, acetonitrile, THF

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CHEM231 (2 decks)

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