Nucleic acids and Nucleotides Flashcards
Nucleic acids
are long, linear polymers constructed from four types of monomers
Each monomer consists of a sugar, a phosphate, and a base.
Name the purines
adenine, guanine
Name the pyrimidines
cytosine, uracil, thymine
Semiconservative replication
the replication process to make two daughter helices from one parent strand and one newly synthesized strand
What is the most common type of structure DNA is seen?
B form or the Watson-Crick helix
Name the 3 types of DNA structures.
B form or the Watson-Crick helix, A form, which is shorter and wider than the B form with the bases at an angle rather than perpendicular to the helix axis and Z DNA
Nucleotide
a nucleoside with one or more phosphoryl groups attached
Nucleoside
a nitrogenous base bound to a sugar
What bases pair together and what kind of bond and how many of that bond do they have?
Hydrogen bonds- A with T, 2
G with C, 3
Chromatin
entire complement of a cell’s DNA and its associated proteins
Nucleosome
Two copies each of histones H2A, H2B, H3, H4 and 200 bp of DNA
What is Cisplatin
a chemotherapeutic agent that reacts with DNA such that nitrogens of adjacent purines replace the chloride atoms.
how sugars are attached to DNA and RNA
In all cases, the C-1’ of the sugar is aLached to the N-9 of the purine or the N-1 of the pyrimidine.