Nucleic Acid Synthesis Inhibitors

Question 1

direct DNA synthesis inhibitors name ?

798

Answer 1

1. quinolones
2. metronidazoles

Question 2

direct RNA synthesis inhibitors name ?

Answer 2

1. rifampicin
2. rifamycin

Question 3

indirect NASI / Anti-folate drugs name ?

Answer 3

1. sulfonamide
2. trimethoprim
3. pyrimethamine

12-25-2024— 3.05

Question 4

Oral absorbable Sulfonamide name ?

Answer 4

1. sulfamethoxazole
2. sulfa- cytine - doxine - pyridine

Question 5

oral non-absorbable sulfonamide name ?

Answer 5

sulfasalazine

Question 6

topical sulfonamide name ??

Answer 6

1. silver - Sulfadiazine
2. Na - sulfacetamide

Question 7

M/A of sulfonamide ?

which enzyme ?

Answer 7

compete with PABA for enzyme
Di-Hydropteroate synthase

Question 8

M/A of trimethoprim ?

Answer 8

Compete with Di-hydrofolate reductase

Question 9

Co-trimoxazole formulation ?

Answer 9

1. sulfamethoxazole - 400mg
2. trimethoprim - 80mg

Question 10

which activity in co-trimoxazole ?

Answer 10

synergictic activity

Question 11

fansidar combination ?

Answer 11

1. sulfadoxine -500mg
2. pyrimethamine - 25mg

Question 12

use of fansidar ?

Answer 12

acute toxoplasmosis

Question 13

oral-absorbable sulfonamide uses ?

Answer 13

1. UTI
2. Acute toxoplasmosis

Question 14

sulfasalazine indication ?

Answer 14

1. ulcerative colitis
2. enteritis

Question 15

which sulfonamide in bacterial conjunctivitis ?

Answer 15

Na-sulfacetamide

Question 16

which sulfonamide in Burn wound ?

Answer 16

silver- sulfadiazine

Question 17

indications of Trimethoprim ?

Answer 17

UTI

Question 18

Indications of Co-trimoxazole ?

Answer 18

1. UTI
2. Otitis media
3. community acquired Pneumonia
4. RTI
5. Shigellosis
6. enteric fever

Question 19

2nd line therapy of malaria which Sulfonam ide ?

Answer 19

fansidar

Question 20

A/E of co-trimoxazole ?

Answer 20

1. crystilluria
2. renal stone
3. allergic reactions
4. megaloblastic anemia
5. hemolytic anemia
6. fever
7. hypersensitivity
8. rashes
9. urticaria

Question 21

advice given to patient ?>

Answer 21

plenty of water to drink

Question 22

A/E of trimethoprim ?

Answer 22

1. megaloblastic anemia
2. leukopenia
3. grnaucytopenia

Question 23

A/E of sulfonamide ?>

Answer 23

1. hypersensitivity
2. crystilluria
3. haematuria
4. nausea
5. vomiting
6. PAN
7. arthritis
8. hepatitis
9. granulocytopenia
10. hemolytic anemia

Question 24

quinolone derivatives name ?

Answer 24

1. nalidixic acid
2. fluroquinolones

Question 25

1st generation fluroquinolone ?

Answer 25

nalidixic acid

Question 26

4th G F ?

Answer 26

1. moxi floxacin 2. gemi floxacin

Question 27

2nd generation F ?

Answer 27

1. levofloxacin 2. o 3. cipro 4. nor

Question 28

3rd Generation F ?

Answer 28

Gatifloxacin

Question 29

which generation most active against G(-) ?

Answer 29

2nd

Question 30

Respiratory quinolones drug name - 1000%

Answer 30

1. levo floxacin 2. gati 3. gemi 4. moxi 5. spar

Question 31

why they are called Respiratory quinolones ?

Answer 31

1. have enhanced gram + activity 2. used in URTI & LRTI

Question 32

M/A of fluroquinolones ?

Answer 32

1. inhibit topoisomerase - II 2. prevent relaxation of positively supercoiled DNA 3. orevent transcription & translation 4. inhibition of DNA & protein synthesis 5. bacterial cell wall death

Question 33

M/A of inhibition of topoisomerase-IV

Answer 33

INTERFERE with sepration of replicated chromosomal DNA from daughter cell

Question 34

Indications of F ?

Answer 34

1. UTI 2. PID 3. Thyphoid 4. Gi infection 5. skin & soft tissue infection 6. osteomyelitis 7. prostatitis 8. intra Ab infection

Question 35

A/E of F ?

Answer 35

1. N-V-Diarrhoea 2. headache 3. dizziness 4. photosensitivity 5. hepatotoxicity 6. prolonged QT interval 7. tendinitis 8. arthropathy

Question 36

which Cephalosporins in UTI ?

Answer 36

1. cephradine 2. cefixime 3. ceftriaxone 1 1 2 3 3

Question 37

# * which penicillin in UTI ?

Answer 37

1. amoxicillin 2. ampicillin 3. A + Calvulinic acid = co-amoxiclav

Question 38

Drugs of UTI ?

Answer 38

1. trimethoprim 2. ciprtofloxacin' 3. coamoxiclav 4. cefuroxime

Question 39

superinfection by which F ?

Answer 39

ciprofloxacin