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Crack the Core > Nuclear Medicine > Flashcards

Nuclear Medicine Flashcards

1
Q

Target organ: liver

A

In-prostascint
I-131
IV sulfur colloid

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2
Q

Target organ: distal colon

A

Gallium

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3
Q

Target organ: bladder

A

MAG 3
MDP
i-123 MIBG

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4
Q

Target organ: renal cortex

A

DMSA

thallium

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5
Q

Target organ: spleen

A

In-wbc
Damages rbcs
Octreotide

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6
Q

Target organ: proximal colon

A

Sestamibi

Oral sulfur colloid

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7
Q

Target organ: gallbladder wall

A

HIDA

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8
Q

Radionuclide purity

  • acceptable
  • test
A
  • 0.15 microCi of Mo-99 per 1 milliCi of Tc-99

- dose calibrator with lead shields: Mo-99 is assayed first

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9
Q

Radiochemical purity

A

Amount of free Tc
95% purity for pertechnetate
92% for sulfur colloid
91% for everything else

-thin layer chromatography

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10
Q

Chemical purity

A

Amount of aluminum

  • 10 micrograms per 1mL
  • pH paper
  • aluminum contamination shows up as lung activity in a sulfur colloid scan and as liver activity in a Tv scan
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11
Q

Xenon-133

  • half life?
  • energy?
A

5.3 days (physical)

80 keV

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12
Q

Gallium-67

  • production?
  • decay?
  • half life?
  • energies?
  • critical organ?
A
  • cyclotron: bombardment of Zn-68
  • half life: 78 hours
  • electron capture; emits gamma rays
  • Energies: 93 keV, 184 keV, 300 keV, 393 keV
  • critical organ: distal colon
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13
Q

I-131

  • half life?
  • energy?
A
  • 8 days

- 364 keV

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14
Q

thyroid formation in fetus

A

8-12 week

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15
Q

Breast feeding

  • Tc 99m ?
  • I -123
  • I-131
A

Tc 99: resume breast feeding in 12-24 hrs
I-123: resume breast feeding in 2-3 days
I-131: stop breastfeeding

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16
Q

when does patient have to be admitted after radioiodine therapy?

A
  • 7mR/h measured at 1 meter from patient’s chest

- 33 mCi of residual activity

17
Q

Thallium-201

  • half life
  • production
  • decay
  • energies
A
  • 73 hours
  • cyclotron
  • decays by electron caputre
  • major emissions are characteristic X rays of daughter product Mercury 201: 69 and 81
18
Q

dose of morphine for HIDA

A

0.02-0.04 mg/kg over 30- 60 minutes

19
Q

dose of CCK for HIDA

A

0.02 micrograms/kg over 60 minutes

20
Q

phenobarbital dosing

A

2.5 mg BID for 5 days (5 mg for 5 days)

21
Q

cyclotron produced; decay by electron capture

A

Th-201, Ga-67, In-111, I-123

emission are gamma rays

22
Q

cyclotron produced, decay by beta plus

A

C-11, N-13, O-15, F-18

23
Q

what interval do you perform FDG PET after therapy?

A

chemo: 2-3 weeks
radiation: 8-12 weeks

24
Q

SUV calculation

A

FDG concentration / (dose/body weight)

25
Q

tumors that are PET cold

A
  • renal cell
  • BAC
  • anything mucinous
  • carcinoid
  • bowel implants/peritoneal implants
  • prostate
26
Q

benign things that are PET HOT

A
  • infection/inflamation
  • ovaries in follicular phase
  • muscles
  • brown fat
  • thymus
  • oncocytomas
27
Q 
Indium-111
-half life
- production
- decay
photopeak
A
  • half life = 67 hours
  • cyclotron
  • electron capture
  • 173 keV, 247 keV
28
Q

agents used to treat bone pain due to breast or prostate mets

A
  • Sr-89 chloride
  • Sm153 EDTMP
  • Ra-223 dichloride
29
Q

absolute contraindications for Sr-89 and Sm-153 treatment

A
  • pregnancy
  • breast feeding
  • renal failure (GFR <30)
30
Q

Sm-89 chloride

A
  • Metastron
  • worst and oldest agent used to treat cancer related bone pain
  • pure beta emitter
  • high myelotoxicity
  • binds to hydroxyapatite where bone turnover is the highest
  • renal excretion
31
Q

Sr-153

A
  • Quadramet
  • 2nd best agent for bone pain
  • binds to hydroxyapatite where bone turnover is the highest
  • beta decay, with 28% of decay gamma rays (103 keV)
  • transient bone marrow suppression that recovers faster than Sr (6-8 weeks vs. 8-12 weeks)
  • renal excretion
32
Q

Ra-223

A

-Xofigo
- emits 4 alpha particles - ds DNA breaks
- absorbed into bone matrix at sites of active mineralization
- side effects are diarrhea, nausea, vomiting, fatigue
long half life (11.4 days)

33
Q

Y-90

A
  • pure beta emitter
  • 175 keV and 185 kEV emissions can be used to image
  • half life = 2.67 days
34
Q

produced in generator

A

Tc-99

Rb-82

Crack the Core (12 decks)

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