NTG and Digoxin Flashcards
NTG is primarily used for what condition? what are other uses?
angina
HTN (crappy), CHF, AMI, pulmonary HTN
NTG decreases preload/afterload?
PRELOAD (end of diastole), from decreased VR
NTG –> NO = vasodilation in what vessels?
mainly venules, some arterioles
NTG causes direct coronary _________.
dilation and increased bloodflow
What limits the efficacy of NTG? what can be done about this?
tolerance.
10-12 hour nitrate-free interval for re-generation of SH groups
AEs of NTG include…
facial flushing, headahce, dizziness
Which NTG is DOC for relief from acute angina attacks?
sublingual (SL) –immediate release
NTG is available ER and IR. What would you use in an acute angina attack?
IR. NOT ER because those are slow on, slow off.
T or F. NTG is available IV and PO. How is the PO available?
True Extended release (IR gets destroyed by stomach)
IV NTG should be compounded in what?
GLASS
Why so we encourage refills of NTG?
Tabs are only potent for 6-12 months and we want everyone with angina to carry it around.
Other than IV and PO, what other ways is NTG available?
Aerosol spray, buccal tabs, ointment, transdermal
SL NTG should ______ when you place it under the tongue.
sting
Guidelines for NTG now is…
Tablet, tablet, ER.
CAUTION when combining NTG and…..what can happen?
PDE-5 inhibitors (erectile dysfunction drugs)
severe hypotension
