NT Flashcards
1
Q
Features of NT
A
Synthesised : in presynaptic terminal
Stored : in vesicles
Released in respinse to nerve impulse :
- nerve impulse cause Ca2+ influx to presynaptic terminal
- exocytosis of NT into synaptic cleft
- NT binds to postsynaptic
Termination :
- reuptake into presynaptic terminal
- enzymatic inactivation
2
Q
Excitatory NT
A
- Ach
- dopamine
- Ne / Epi
- histamine
- Glutamate
3
Q
Inhibitory NT
A
- GABA
- Glycine
4
Q
2 receptor of Ach
A
- Nicotinic (excitatory) on NMJ
2. Muscarinic (both) in brain
5
Q
Too much & little Ach
A
Much : Muscle contraction (spasm)
Little : Paralysis / Alzheimer’s disease
6
Q
Too much & little dopamine
A
Much : Schizophrenia
Little : Parkinson’s disease
7
Q
Too little serotonin
A
Depression
8
Q
Principal excitatory NT in CNS
A
Glutamate
9
Q
Predominant inhibitory NT in brain
A
GABA
10
Q
Key enzyme & coenzyme of GABA synthesis
A
Key enzyme : Glutamic acid decarboxylase
Coenzyme : Pyridoxal phosphate
11
Q
What happen in myaesthenia gravis ?
A
Ach receptor in muscle is markedly reduced
