NSAIDS PART 2 Flashcards
which is the correct comparison of dosages for aspirin?
a. antiplatelet > anti-inflammatory
b. antiplatelet < antipyresis
c. anti-inflammatory < antipyresis
d. antipyresis > analgesic
antiplatelet < antipyresis / analgesic < anti-inflammatory
80-160 , 160-325, 325-650 mg
which two aspirin dosages are equal??
a. antiplatelet and analgesic
b. antiplatelet and antipyretic
c. anti-inflammatory and analgesic
d. analgesic and antipyretic
e. none of the above
antipyretic = analgesic
Which is a salicylate-like NSAID and a COX2 inhibitor?
a. ketorolac
b. celebrex
c. ibuprofen
celebrex is a COX2 inhibitor!
salicyclate-like NSAID’s with the suffix “coxib” are all inhibitors of what?
a. COX1
b. COX2
coxib = COX2 inhibitors
ketorolac is least COX2 selective while rofecoxib is most COX2 selective
true
which has the longest plasma half-life?
a. ketorolac
b. celecoxib
c. ibuprofen
d. piroxicam
piroxicam
ibuprofen is least GI toxic while piroxicam is most GI toxic.
true
for plasma half life, acetaminophen < aspirin < ibuprofen < ketorolac < celecoxib
TRUE! acetaminophen has shortest half life compared to the others.
Which can elevate IOP, cause cataracts, cause HPA axis effects, and has risk of post-op cystoid macular edema?
a. NSAIDs
b. Steroids
Steroids
Which has “ceiling effect” (maximum limit of analgesia regardless of dose)?
a. NSAIDs
b. OPIOIDS
NSAIDs
All of the following are true statements, except:
a. Opioids have no ceiling effect.
b. NSAIDs cause mydriasis
c. NSAIDs are non-addictive while Opioids are addictive.
d. Opioids have topicals available.
e. NSAIDs are for anti- inflam, anti-platelet and anti-pyresis; Opioids are NOT for anti-inflam, antipyretic, anti-platelet.
Opioids do not have topical form. only non-topical!
which is for peripheral pain?
a. acetaminophen
b. aspirin
aspirin
which is safe in pregnant women?
a. acetaminophen
b. aspirin
acetaminophen (tylenol) is safe in pregnant women
is acetaminophen anti-inflammatory and anti-platelet?
no, it is not because it is NOT an NSAID.
what is the treatment plan for a patient who overdoses on aspirin?
dialysis!
All of the following describe “Reye’s Syndrome”, except:
a. adverse reaction in children taking aspirin to reduce fever in a bacterial infection.
b. causes GI disturbances and liver degeneration.
c. can cause encephalopathy.
d. mortality rate is 35%
a is false. it affects the treatment of VIRAL infections such as chicken pox or influenza
when children have fevers, they should take tylenol or ibuprofen, instead of aspirin.
true
which is not true of aspirin?
a. anti inflammatory
b. anti platelet
c. not good for pregnant women
d. no GI effects
e. none of the above
no GI effects is false!!! aspirin does cause GI disturbances.
aspirin is eliminated in the liver; tylenol is eliminated in the kidney.
false! the other way around.
aspirin –> kidney (that’s why dialysis is the treatment if overdose on aspirin).
NSAIDs can interact with:
a. other NSAIDs
b. steroids
c. anticoagulants
d. omega 3
e. gingko biloba
f. all of the above
all of the above!
if patient is taking beta blockers for glaucoma, is it safer to take aspirin or acetaminophen?
don’t give aspirin!
which topical NSAID is most prescribed to treat allergic conjunctivitis (AC)?
a. flurbiprofen
b. ketorolac
c. diclofenac
d. bromfenac
ketorolac!!!
cyclosporine-A is the first immunosuppressant on the market to treat _______.
dry eye
cyclosporine-A is also called __________.
Restasis
cyclosporine-A (restasis) reversibly reduces pro-inflammatory T-helper cell cytokines, such as IL-2, IL-4, IFN-gamma, and TNFa, as well as inhibits mast cell degranulation.
true
cyclosporine-A is contraindicated against patients with active ocular infection, or known hypersensitivity.
true
cyclosporine-A is preservative free
true
