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Disease and Defense: Pharmacy Grinding -Unit II > NSAIDs and Glucocorticoids > Flashcards

NSAIDs and Glucocorticoids Flashcards

1
Q

Salicylates

A

Traditional- Inhibits COX-1 and COX-2 reversibly

-Analgesic, antipyretic, anti-inflammatory

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2
Q

Pyrazolone

A

Traditional- Inhibits COX-1 and COX-2 reversibly

  • Analgesic, antipyretic, anti-inflammatory
  • Potent, long lasting, but toxicity problems
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3
Q

Indomethacin [Indocin]

A

Traditional- Inhibits COX-1 and COX-2 reversibly

-Analgesic, antipyretic, anti-inflammatory

Acetic/carboxylic acid

  • Fewer toxic reactions than Pyrazolones
  • Many adverse reactions with this particular one
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4
Q

Ketoralac [Toradol]

A

Traditional- Inhibits COX-1 and COX-2 reversibly

-Analgesic, antipyretic, anti-inflammatory

Acetic/carboxylic acid

  • Fewer toxic reactions than Pyrazolones
  • Be very cautious prescribing to elderly with GI bleed, renal impairment
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5
Q

Nabumatone [Relafen]

A

Traditional- Inhibits COX-1 and COX-2 reversibly

-Analgesic, antipyretic, anti-inflammatory

Acetic/carboxylic acid

  • Fewer toxic reactions than Pyrazolones
  • Long half-life
  • Somewhat Cox-2 selective
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6
Q

Meloxicam [Mobic]

A

Traditional- Inhibits COX-1 and COX-2 reversibly

-Analgesic, antipyretic, anti-inflammatory

Oxicam derivative

  • Potent, long half-life
  • Lower GI side effects
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7
Q

Ibuprofen [Motrin, Advil]

A

Traditional- Inhibits COX-1 and COX-2 reversibly

-Analgesic, antipyretic, anti-inflammatory

Proprionic Acid Derivatives
-Well Tolerated

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8
Q

Naproxen [Naprosyn, Aleve]

A

Traditional- Inhibits COX-1 and COX-2 reversibly

-Analgesic, antipyretic, anti-inflammatory

Proprionic Acid Derivatives
-Well Tolerated

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9
Q

Ketoprofen [Orudis]

A

Traditional- Inhibits COX-1 and COX-2 reversibly

-Analgesic, antipyretic, anti-inflammatory

Proprionic Acid Derivatives
-Well Tolerated

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10
Q

Acetaminophen

A

COX-2 at CNS only

-Analgesic, antipyretic

  • No anti-inflammatory
  • Not true NSAIDs
  • Fewer GI effects
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11
Q

Celecoxib [Celebrex]

A

Inhibits COX-2 only, reversibly

  • Analgesic, antipyretic, anti-inflammatory
  • Fewer GI side-effects
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12
Q

Aspirin [acetylsalyclic acid]

A

Inhibits COX-1 and COX-2 irrebersibly

-Analgesic, antipyretic, anti-inflammatory, antithrombotic

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13
Q

Diclofenec [Voltaren]

A

Traditional- Inhibits COX-1 and COX-2 reversibly.

-Analgesic, antipyretic, anti-inflammatory

Acetic/carboxylic acid
-Fewer toxic reactions than Pyrazolones

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14
Q

Cortisol

A

Common for replacement therapy in emergencies.

  • Equal glucocorticoid and mineralocorticoid effects
  • Orally or parenterally
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15
Q

Prednisone

A

Most common oral agent when a steroid burst therapy is desired.

  • [3:1] glucocorticoid to mineralocorticoid action
  • Activated in liver by first-pass metabolism
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16
Q

Methylprednisolone [Medrol/ Solu-Medrol]

A

Used for perenteral version of steroid burst.

-Minimal mineralocorticoid action

17
Q

Dexamethasone [Decadron]

A

Most potent anti-inflammatory. Used in cerebral edema, chemotherapy-induced vomiting.

-No mineralocorticoid action, greatest suppression of ACTH at the pituitary

18
Q

Triamcinolone [Kenalog]

A

Potent systemic agent.

  • No mineralocorticoid action
  • Excellent topical activity
19
Q

Fludrocortisone [Florinef]

A

Mildly anti inflammatory and strongly mineralocorticoid

Oral dosing

Disease and Defense: Pharmacy Grinding -Unit II (1 decks)

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