NSAIDS and Acetaminophen

Question 1

Acute pain is either ___ or ___.

Answer 1

Nociceptive or Inflammatory

Question 2

TRPA receptor

Answer 2

extreme cold

Question 3

ASIC receptor

Answer 3

acid

Question 4

TRPV1 receptor

Answer 4

capsaicin

Question 5

P2X receptor

Answer 5

activated by ATP

Question 6

GPCR

Answer 6

bind prostaglandins that can drive pain/inflammation

Question 7

Where do primary nociceptors synapse with secondary nociceptors?

Answer 7

dorsal root ganglia of spinal cord

Question 8

What is the main excitatory NT of the CNS that is also released by primary nociceptors in the synaptic cleft?

Answer 8

Glutamate

Question 9

sharp, aching, throbbing pain

Answer 9

nociceptive pain

Question 10

sharp, aching, throbbing pain with swelling, redness, warmth

Answer 10

inflammatory pain

Question 11

inflammatory agents all activate what?

Answer 11

silent nociceptors to produce pain

Question 12

inflammatory agents can activate pain but also induce ____.

Answer 12

hyperalgesia

Question 13

Outline the steps following prostaglandin binding to its GPCR. What are the two main effects of this?

Answer 13

1. prostaglandin binds to EP/IP receptor
2. activates PKA/PKC through secondary messengers
3. PKA and PKC phosphorylate ion channels to increase their activity. These channels include TRPV1 channels, Na channels, K channels.
4. Increases sensitivity to activating pain signals so that previous signals that failed to activate nociceptors now produces pain (allodynia)
5. Also allows channels to produce larger receptor potentials to generate higher frequency APs and hyperalgesia