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Pharmacology > NSAIDs > Flashcards

NSAIDs Flashcards

1
Q

Most likely true of excretion of salicylates?

A. excretion depends on the dose and urinary pH

B. excretion is high at pH 8 & 6

C. GFR is high at pH 8

D. All of the above

A

D.

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2
Q

Patient is on antiplatelet dose and at the same time, he is taking aspirin? What is the t 1/2 of aspirin?

A. 2-3 hr
B. 20 min
C. 12 hr
D. 15-30 hr

A

A. On antiplatelet doses 2-3 hr

20 min= plasma t 1/2
12 hr= anti-inflammatory doses
15-30 hr= high therapeutic doses or intoxication

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3
Q

Detoxication of salicylates during overdose.

A. Hemodialysis
B. Hemofiltration Techniques
C. Both A & B
D. None of the above

A

C.

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4
Q

Significant adverse effects of Aspirin is seen on?

A. > 300 ug/mL
B. 400 ug/mL
C. > 200 ug/mL
D. 500 ug/mL

A

A

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5
Q

The analgesic-antipyretic dose of aspirin for adults?

A

325-1000 mg OD q 4-6 hr

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6
Q

The anti-inflammatory dose of aspirin?

A

4-8 g/d in divided doses

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7
Q

The max recommended daily dose of aspirin for adults and children is ?

A

4 g

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8
Q

Maintenance dose of diflusinal should not exceed?

A

250-1000 mg/day

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9
Q

Potent anti-inflammatory drug but NO antipyretic effects, 3-4x times more potent than aspirin?

A

Diflusinal

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10
Q

Salicylates that causes auditory side effects

A

Diflusinal

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11
Q

Plasma concentration of salicylates that causes hepatic injury?

A

> 150 ug/mL

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12
Q

Large doses of salicylates can cause?

A

Hyperglycemia
Glycosuria
Deplete liver and muscle glycogen

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13
Q

Dose of salicylates that lowers the plasma concentration of iron and shorten erythrocyte survival time.

A

3-4 g/day

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14
Q

Aspirin can cause _______ in px with G6PD deficient

A

Mild Hemolysis

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15
Q

Dose of sodium salicylate or aspirin the causes dearh in adults

A

10-30 g

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16
Q

Trimester that is avoided in salicylate used in pregnancy

A

3rd trimester

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17
Q

Specific antidote for salicylate poisoning

A

NO

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18
Q

Active metabolite of phenacetin

A

Acetaminophen

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19
Q

The maximum FDA-recommended dose of acetaminophen

A

4 g/d

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20
Q

Acetaminophen undergoes CYP-mediated N-hydroxylation to forming the highly reactive

A

NAPQI

if large doses of acetaminophen is taken, it depletes GSH = toxic overdose

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21
Q

The conventional oral dose of acetaminophen

A

325-650 mg q 4-6 hr

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22
Q

Daily dose of Acetaminophen should not exceed

A

4 g

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23
Q

For chronic alcoholics, daily dose of Acetaminophen should not exceed

A

2 g/d

24
Q

Most serious acute adverse effect of overdosage of acetaminophen

A

Fatal hepatic necrosis

25
Q

Dose in adults that cause hepatotoxicity

A

10-15 g (150-250 mg/kg)

doses > 20-25 are fatal

26
Q

T 1/2 of Diclofenac

A

1-2 hr

27
Q

Opthalmic solution of this drug will treat postoperative inflammation following cataract extraction

A

Diclofenac

28
Q

Reactive metabolite of Diclofenac that is similar with NAPQI that depletes GSH

A

Benzoquinone Imines

29
Q

20x times more potent than aspirin, intolerance limits its use

A

Indomethacin

30
Q

Only COX-2 inhibitor approved in the US

A

Celecoxib

31
Q

Selective COX-2 inhibitors loses GI advantage over the NSAIDs alone when in used in conjunction with

A

Aspirin

32
Q

Peak plasma level of Celecoxib

A

2-4 hr

33
Q

Recommended dose of Celecoxib for Osteoarthritis

A

200 mg/d SD or DD

34
Q

Recommended dose of Celecoxib for rheumatoid arthritis

A

100-200 mg BID

35
Q

T 1/2 of Etoricoxib

A

20-26 hr

36
Q

T 1/2 of Celecoxib

A

11.2 hr

37
Q

Aspirin is deacetylated in?

A

Intestinal Wall
RBC
Liver

38
Q

Aspirin is deacetylated through?

A

Hydrolysis and Esterases

39
Q

In px with RA, salicylate can cause?

A

Hypoalbuminemia

40
Q

MOA of salicylate

A

interferes transcription binding to COX-2 promoter

41
Q

Oral salicylates are absorbed rapidly in the?

A

Small Intestine

42
Q

Peak plasma level of salicylates is about?

A

1 hr

43
Q

Salicylates are transported out of the CSF

A

Actively across choroid plexus

44
Q

Salicylate are transported to tissues by?

A

pH-dependent processes

45
Q

Rate of absorption of salicylates are determined by the?

A

Disintegration & Dissolution rates of Tablets

pH

mucosal surface

gastric emptying time

46
Q

Causes pseudoresistance of salicylates

A

food and enteric coating

47
Q

pH that will increase the solubility and dissolution of salicylates and its ionization

A

alkaline (rise in pH)

48
Q

Acetate ester of salicylic acid

A

Aspirin

49
Q

T 1/2 of Diflusinal

A

8-12 hr

50
Q

T 1/2 of Acetaminophen and Indomethacin

A

2 hr

51
Q

T 1/2 of Sulindac

A 
7 hr
18 hr (active sulfone metabolite)
52
Q

T 1/2 of Etodolac

A

7 hr

53
Q

T 1/2 of Tolmetin

A

5 hr

54
Q

T 1/2 of Ketorolac

A

4-6 hr

55
Q

T 1/2 of topical epolamine patch of Diclofenac

A

12 hr

56
Q

T 1/2 of Nabumetone in Elderly

A

22-38 hr

57
Q

T 1/2 of Nabumetone

A

19-26 h

Pharmacology (4 decks)

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