NSAIDs

Question 1

What is the mechanism of NSAIDs?

Answer 1

Inhibit COX and hence, reduce thromboxane, prostacyclin, and prostaglandin production (responsible for mediating inflammation and sensitizing peripheral nerve endings)

Question 2

What are the two forms of COX enzymes?

Answer 2

COX-1 - constitutive - responsible for physiological production of PGs

COX-2 - inducible - produces PGs during inflammation

Question 3

What are the two drugs that primarily inhibit COX-2 in dogs ?

Answer 3

Firocoxib and Robenacoxib

Question 4

What is the drug that primarily inhibit COX-2 in horses?

Answer 4

Etodolac