NSAIDs Flashcards
T/F: COX inhibits TXA2 production.
FALSE! COX is actually the enzyme responsible for TXA2 production.
What are the 5 cardinal signs of inflammation?
Heat, redness, swelling, pain and loss of function
which of the following is not one of the 5 cardinal signs of inflammation?
a. calor
b. rubor
c. tumour
d. dolor
e. functiolaesa
f. none of the above
f. none of the above. They are all signs of inflammation
Pain (dolor) promotes healing because you will stop moving the injured area, allowing the immune system to be efficient. If you keep moving that area it’s never gonna heal!
True! Understand this concept
The ________ response = A pathological process characterized by injury or destruction of tissues caused by variety of cytologic and chemical reactions.
INFLAMMATORY response
what 3 things does the inflammatory response do?
- isolate injurious agent
- remove cell debris and pathogens
- prepares site for tissue repair
The inflammatory pathway in the CNS predominantly affects ______ activity.
neuronal activity
Lipocortin (aka lipomodulin) is an annexin protein that inhibits ______?
a. PGH2
b. PGG2
c. PLA2
d. PLA1
e. PGF2a
PLA2 (phospholipase a2)
Which 2 are pro-inflammatory, sensitize nerves to pain, and increase activity of bradykinin + histamine?
a. PGD2
b. PGE2
c. PGI2
d. PGF2a
PGE2 and PGF2a
TXA2 is an antagonist of ______.
a. PGG2
b. PGE2
c. PGI2
d. PGD2
PGI2
T/F: TXA2 is a platelet inhibitor while PGI2 is a platelet aggregator.
False!!! TXA2 causes platelet AGGREGATION while PGI2 inhibits platelets.
_______ is an example of a COX inhibitor.
Aspirin
COX = cyclooxygenase
True!!!
PGE2 is pro-inflammatory and causes edema, hypothermia, and vasoconstriction.
False!!! PGE2 is pro-inflammatory, which means it is capable of producing an inflammatory response. Therefore it causes edema, HYPERthermia, and vasoDILATION.
Arachidonate ——-> PGG2 is caused by which enzyme?
a. acetyl transferase
b. thromboxane synthase
c. phospholipase A2 (PLA2)
d. cyclooxygenase (COX)
e. 5-lipoxygenase
COX!!
T/F? Arachidonate —-> PGG2 —-> PGH2 —–> PGI2, PGE2, PGD2, PGF2a, and TXA2.
True
PGH2 —–> TXA2 is caused by which enzyme?
a. isomerase
b. PLA2
c. thromboxane synthase
d. acetyl transferase
thromboxane synthase
ARACHIDONATE —?—> HPETE —-> LTA4 (other leukotrienes) is caused by what enzyme?
a. isomerase
b. PLA2
c. 5-lipoxygenase
d. PGI2 synthase
5-lipoxygenase
PGH2 – isomerases—> ? ? ? (choose 3)
a. PGE2
b. PGI2
c. PGD2
d. TXA2
e. PGF2a
PGE2, PGF2a, and PGD2 are formed by isomerases.
Note that TXA2 is produced by thromboxane synthase , and PGI2 is produced by PGI2 synthase.
omega3 comes from red meat.
False. omega6 comes from red meat.
most north americans consume enough red meat so they don’t need ______ supplements.
a. omega3
b. omega6
don’t need omega6 supplements
most north americans need to take ______ supplements.
a. omega3
b. omega6
omega3 supplements
T/F: Delta-5-desaturase favors DHLA over eicosatetraenoic acid.
false. it favors eicosatetraenoic acid (omega3 pathway)
what is the source of omega3 for fish?
algae
T/F: Both omega3 and omega6 are essential fatty acids.
True, both are essential, get them from our diet.
T/F: Evening Primrose Oil is associated with Omega3 while Fish and Flaxseed Oils are associated with Omega6.
False!!!
Evening Primrose Oil = Omega6
Fish and Flaxseed Oils = Omega3
T/F: Evening primrose oil consists of linoleic and gamma linolenic acids.
True
Flaxseed oil and Evening primrose oil _____ platelet aggregation.
a. increase
b. reduce
reduce