NSAIDS

Question 0

Mechanism of action of NSAIDS

Answer 0

Inhibit cyclooxygenase enzymes and anti platelet agents

Question 1

Safety of NSAIDS

Answer 1

Pre conception - may inhibit ovulation, affect fertility and increase risk of pregnancy loss

First trimester - congenital heart defects

Second trimester - low birthweight

Third trimester - impaired renal function and oligohydramnios 
Constriction of ductus arteriosus
NEC
intracranial haemorrhage 
Risk of asthma for the future