NSAIDs Flashcards
1
Q
What does NSAIDs stand for?
A
Non-Steroidal Anti-Inflammatory Drugs
2
Q
What are the 5 cardinal signs of inflammation?
A
Heating, Redness, Swelling, Pain, Loss of Function
3
Q
What are some Eicosanoids?
A
Prostaglandins
Prostacyclin
Thromboxane
4
Q
What is the Arachidonic Acid cascade?
A
Membrane phospholipids > Arachidonic Acid > PGG2 > PGH2 > Prostaglandins
5
Q
What are COX1 and COX2?
A
Cyclooxygenase and Peroxidases
6
Q
Where can COX1 and COX2 be found?
A
COX1 — Constitutive in most cells for homeostasis and housekeeping
COX2 — Inducible by IL-1B and TNF-a, Constitutive in kidney, female reproductive tract, CNS
