NSAIDs /تمري

Question 1

NSAIDs for gout except…………, which appears to be ineffective .

Answer 1

tolmetin

Question 2

All NSAIDs except 1-…………..2-………… inhibit platelet aggregation

Answer 2

1-COX-2–selective agents
2-nonacetylated salicylates

Question 3

گشت ئةي دةرمانةيلة ، ترشي ئةندامي لاوازن بيجگة لة

Answer 3

Nabumetone, is a ketone prodrug that is metabolized to the acidic active drug.

Question 4

NSAID metabolism proceeds, in large part, by way of the…………… families of P450 enzymes in the liver

…………is the most important route for final elimination.

All NSAIDs can be found in…………after repeated dosing.
nearly all undergo varying degrees of biliary excretion and reabsorption

Most of the NSAIDs are highly protein-bound……… usually to albumin.

Several NSAIDs (including aspirin) reduce the incidence of………… when taken chronically

Answer 4

CYP3A or CYP2C

Renal excretion

synovial fluid

(∼ 98%)

colon cancer

Question 5

Aspirin

Non-selective COX-inhibitors

Selective COX-2 inhibitor

Answer 5

Irreversible

Reversible

Reversible

Question 6

COX-2 inhibitors

Answer 6

Celecoxib

Meloxicam

Question 7

Adverse effects of COX-2 inhibitors

Answer 7

CNS
Cadiovascular اكثر/thrombosis ,HTN,MI,edema
GIT ولكن أقلل
Hepatic
Pulmonary
Renal
Skin /وةسبب زيادبوون لوكوترين
Hematologic /👇/Cytopenia

Question 8

…………of the urine increases the rate of Excretion of free salicylate from aspirin

Answer 8

Alkalinization

Question 9

عارض جانبي مشترك بين گشت NSAIDs

Answer 9

تسمم كلوي + حساسية بسبب زيادبووني لوكوترينات

Question 10

…………may be valuable in treating preeclampsia-eclampsia

Answer 10

Aspirin

Question 11

All nonacetylated salicylates

Answer 11

منع رفاقةتي صفيحات دموية نيكةد

Question 12

Adverse effects of aspirin

Answer 12

Gastric upset
Hepatotoxicity
حساسية بكل انواعه

Question 13

COX-2 inhibitors
تأثير نيكةد لة رفاقةتي الصفائح الدموية

عادتاً تداخل دوائي ديرد وةل………

Answer 13

But They do inhibit COX-2-mediated prostacyclin synthesis in the vascular endothelium.

وارفارين

Question 14

Diclofenac with…………👇 upper gastrointestinal ulceration but may result in diarrhea.

Diclofenac + ……………cause renal adverse effects in high-risk patients.

Answer 14

میسوپروستول/ شربت میزو خوریةد ، معدة وامعاء

اومیپرازول

Question 15

Elevation of serum aminotransferases occurs more commonly with this drug than with other NSAIDs.

Answer 15

ديكلوفيناك /ڤولتارين

سولين داك

Question 16

Other forms of diclofenac

Answer 16

1/A 0.1% ophthalmic preparation / prevention of postoperative ophthalmic inflammation.

2/A topical gel containing 3% diclofenac is effective for solar keratoses.

3/rectal suppository form can be considered for preemptive analgesia and postoperative nausea.

Question 17

……………is subject to capacity-limited metabolism.

Answer 17

دايفلونيسال

Question 18

……………affect tumor necrosis factor α (TNF-α) and nitric oxide synthesis.

Answer 18

فلوربي پروفين

Question 19

Other formulations of flurbiprofen

خةتةرة ، چدة ناو عمليات و قورگ

Answer 19

-Topical ophthalmic formulation for inhibition of intraoperative miosis.

-Flurbiprofen IV is effective for perioperative analgesia in minor (ear, neck, nose )surgery.

-lozenge form for sore throat.

Question 20

Other forms of ibuprofen

Answer 20

A topical cream preparation.

A liquid gel preparation of ibuprofen/ provides prompt relief and good overall efficacy in post-surgical dental pain.

Question 21

The drug is relatively contraindicated in individuals with :-
nasal polyps
angioedema
bronchospastic reactivity to aspirin.

Answer 21

Ibuprofen

Question 22

NSAIDs that decrease urine output

Answer 22

Indomethacin > Ibuprofen

Question 23

استخدامات اندوميثاسين

Answer 23

1/An ophthalmic preparation /conjunctival inflammation and to reduce pain after traumatic corneal abrasion.

2/Epidural injections /in postlaminectomy syndrome

3/Gingival inflammation/oral rinse.

Question 24

Accelerate closure of patent ductus arteriosus.

Answer 24

اندوميثاسين

آيبوپروفين

Question 25

كيتوپروفين

Concurrent administration of………… elevates ketoprofen levels and prolongs its plasma half life.

Its major adverse effects are on the……………and ……………

Answer 25

inhibits both COX (nonselectively) and lipoxygenase.

probenecid

GI tract and the central nervous system

Question 26

……………free fraction is significantly higher in women than in men, but half-life is similar in both sexes

Answer 26

ناپروكسن

Question 27

Naproxen adverse effects

Answer 27

1/Rare cases of allergic pneumonitis.
2/leukocytoclastic vasculitis
3/pseudoporphyria

Question 28

كمترين نصف حياة

زياترين نصف حياة وماقبلها

Answer 28

اسپرين

ئوگزاپروزين

پيروكسي كام

Question 29

استعمالات سولين داك

اعراض جانبي سولين داك

Answer 29

Suppresses familial intestinal polyposis.

inhibit the development of colon, breast, and prostate cancer in humans.

Stevens-Johnson epidermal necrolysis syndrome ,thrombocytopenia, granulocytosis, and nephrotic syndrome.

Question 30

Which NSAID For patients with renal insufficiency:

Answer 30

Nonacetylated salicylates

Question 31

……………is less effective than other NSAIDs for AS.

Answer 31

Aspirin

Question 32

In large doses of acetaminophen , a minor but highly reactive metabolite…………… is important because it is toxic to both liver and kidney

Answer 32

N-acetyl-p-benzoquinone

Question 33

Acetaminophen indications

Answer 33

headache, myalgia, postpartum pain.

Question 34

ingestion of……… of acetaminophen may be fatal, Even……… is associated with increased liver function test abnormalities.

Answer 34

15g/// 4g

Question 35

With larger doses of ……………, dizziness, excitement, and disorientation may occur.

Answer 35

Acetaminophen

Question 36

Hemolytic anemia and methemoglobinemia with

Answer 36

Acetaminophen