NSAIDs Flashcards
Aspirin: Mechanism and Toxicity
blood brain barrier? Dosage
Mechanism: IRREVERSIBLE inhibition of COX-1 and COX-2
Toxicity: GI, Hepatic, Hypersensitivity, Reyes Syndrome, Salicylism
*Crosses Blood Brain Barrier
Dosage: 4 grams daily but 2 in alcoholics
Diflusinal
Mechanism: REVERSIBLE inhibiton of COX-1 and COX -2
Toxicity: GI (mild), headache, renal, hypersensitivity
Indomethicin: Mechanism, Toxicity, Clinical Use
Mechanism: REVERSIBLE Inhibition of COX-1 and COX-2
Toxicity: GI, Prolong gestation, Renal
CNS: Headache and aggravate depression
Use: RA, Not for Juvenile RA, Osteoarthritis, Tocolytic agent (Drugs that prevent preterm labor and immature birth by suppressing uterine contractions)
Etodolac: Mechanism and Toxicity
Mechanism: REVERSIBLE Inhibition of COX-1 and COX-2 (MORE COX-2 selectivity)
Toxicity: GI - less severe than Indomethacin
Diclofenac: Mechanism and Toxicity
Mech: REVERSIBLE Inhibition of COX-1 and COX-2
Tox: GI
CNS: dizziness and headache
Toimetin: Mechanism and toxicity
Mech: REVERSIBLE inhibition of COX-1 and COX-2
Tox: GI
CNS: Headache
- Caution: Anaphylactoid reactions!!!
Ketorolac: Mech and Tox
Mech: REVERSIBLE Inhibition of COX-1 and COX-2
Tox: GI
CNS: headache
Ibuprofen
Mech: REVERSIBLE inhibition of COX-1 and COX-2
Tox: Less GI than aspirin or indomethacin
Ocular disturbances
Hypersensitivity: rash / dermatitis
Avoid during pregnancy or breast feeding
Naproxen
Mech: Reversible inhibition of COX-1 and COX-2
Tox: GI less than indomethacin
CNS: headache < indomethacin
Hypersensitivity
Ketoprofen
Mech: REVERSIBLE inhibition of COX 1 and 2
Tox: GI 30%
CNS: headache
Oxaprozin
Mech: COX 1 and 2 inhibitor (once daily)
Tox: GI
Piroxican
Mech: REVERSIBLE inhibition of COX-1 and 2
Tox: GI
Meloxicam
Mech: Inhibits COX-1 and 2 but more COX-2
Tox: GI
Nabumetone
Mech: COX 1 and 2 but more COX-2
Tox: GI
CNS: headache
What to give for acetaminophen overdose
N-acetylcysteine