NSAID use Flashcards
Tylenol dosage
650 mg ever 4-6 hours, max 4g
Aspirin dosage
650 mg every 4 hours, max 4 g
ibuprofen dosage
200-400 mg every 4-6 hours, max 1200 mg
naproxen dosage
220 mg ever 8-12 hours, max 660 mg
acetaminophen considerations in elder
use <3g per day
acetaminophen renal considerations
- GFR 10-50 dose q6h
- GFR <10 dose q8h
aspirin renal/hepatic considerations
avoid if GFR <10 or severe liver disease
ibuprofen renal considerations
avoid if eGFR <60
naproxen renal considerations
avoid if CrCl <30
contraindications for otc pain treatment
- mod to severe
- last >10 days
- increases intensity
- back pain and loss of bowel/bladder control
- accompanying N/V/fever
- 3rd tri of pregnancy
- history of liver disease
- signs of injury
- deformed joint, abnormal movement
- <2 years old
acetaminophen uses
analgesic
antipyretic
acetaminophen preferred populations to use in
- anticoagulat medications
- aspirin allergy
- children with fever
acetaminophen side effects
rash, hepatotoxicity, renal failure in high chronic doses
acetaminophen drug interactions
warfarin
alcohol
cholestyramine
NSAID uses
analgesic
anti-inflammatory
antipyretic
NSAIDs side effects
N/V/D, dyspepsia, rash, dizziness
NSAID drug interactions
- ACEi
- ARB
- diuretics
- anticoagulants
- SSRI
- corticosteroids
contraindications of NSAIDs
- active peptic ulcer
- GI bleed
- Hx of ulcers
- 3rd trimester of pregnancy
misoprostol use
help prevent ulcerations when using NSAIDs/COX-2i
misoprostol contraindication
pregnancy
misoprostol side effects
diarrhea
abdominal pain
signs of hepatotoxicity
- nausea
- fatigue
- lethargy
- jaundice
- upper right quadrant pain
when to notify clinicians about pts on NSAIDs
- suspected pregnancy
- sign of GI toxicity
- sign of hepatotoxicity
aspirin side effects
nausea, vomiting, anti-platelet effect, decreased urate excretion
