NRTIs Details

Question 0

What test is needed prior to abc therapy?

Answer 0

HLA-b*5701, only use abc if test is negative

Question 1

What are NRTI class AEs?

Answer 1

Lactic acidosis

Hepatic stenosis

Question 2

Use abc with caution in what patients?

Answer 2

Increased cvd risk or pre-art viral load over 100,000

Question 3

Abc AEs?

Answer 3

Hypersensitivity: fever, rash, nvd ab pain, malaise, achiness, dyspnea, cough, pharyngitis

Question 4

Abc pg category?

Answer 4

C

Question 5

Didanosine AEs

Answer 5

Peripheral neuropathy, pancreatitis, diarrhea, nausea, maybe portal htn

Question 6

Didanosine pg category

Answer 6

B

Question 7

Emtricitabine why is abrupt withdrawal bad?

Answer 7

Chronic hbv flare

Question 8

Emtricitabine AEs

Answer 8

Increase pigment of palms n soles

Question 9

Emtricitabine pg category

Answer 9

B

Question 10

Abrupt withdrawal of lamivudine

Answer 10

Chronic hbv flare

Question 11

Stavudine AEs

Answer 11

Peripheral neuropathy, pancreatitis, lipotrophy, increase lipids, nm weakness, osteopenia

Question 12

Tenofovir abrupt withdrawal

Answer 12

Chronic hbv flares

Question 13

Tenofovir AEs

Answer 13

Flatulence, ha, renal insufficiency, falconi’s syndrome (proximal renal tube dz where glucose, AAs, uric acid, phos, and bicarbonate aren’t reabsorbed)

Question 14

TDF pg category

Answer 14

B

Question 15

Zidovudine AEs

Answer 15

Ha, n, nail or skin pigment increase, decrease hgb/hct, decrease WBC, increase mcv, myopathy

Question 16

Zidovudine pg category

Answer 16

C

Question 17

Stavudine pg category

Answer 17

C