NOTES FROM SAMPLEX

Question 1

How many doses needed to get:
90% elimination?
95% elimination?
99% elimination?

Answer 1

4, 7, 9

Question 2

How to decrease GET?

Answer 2

Cold drinks, 
Lie down to the right
Billroth's syndrome
Mild Exercise
Domperidone

Question 3

Competitive vs Noncompetitive Agonist:

Affinity? Efficacy? Reversible?

Answer 3

Both has affinity and efficacy.

Noncompetitive is irreversible

Question 4

2 laws that recognizes Herbal Medicine

Answer 4

Administrative Order 172 and 184. Both in 2004

Question 5

Examples of non predictable clinical side effects

Answer 5

Headache, tinnitus, nausea, dizziness, epigastric distress, fatigue, heart burn and vertigo

Question 6

Pharmacologic screening of a drug provides?

Answer 6

Bioavailability, pharmacokinetics, capacity to cause tachyphylaxis, tolerance and drug dependence, determination of ED(50), deine activity and selectivity of the drug

Question 7

Characteristics of Acute Toxicity Studies

Answer 7

single dose, 2 mammalian species, both parenteral and oral route, observed for 14 days

Question 8

Allosteric Activator:

Inc/Dec - Efficacy? Potency?

Answer 8

Inc Efficacy of the drug

Question 9

Tamoxifen is agonistic in?

Answer 9

Uterus

Question 10

CYP450, Phase 1 or Phase 2 enzyme?

Answer 10

Phase 1 since CYP450 is an oxidoreductase