Notes Flashcards
1
Q
Triggers of asthma
A
Allergens- mites, pollen Infection Drugs Eexercise Cold/Hyperventilation Food Pollution Laughter Gerd Stress
2
Q
Pathogenesis of asthma
A
Inflammation Hypersecretion of mucus Constriction Swelling- hyperttophy and thickening Narrowing of airways Symptoms
3
Q
How does airway remodeeling occur
A
epithelial shedding Sub epithelial fibrosis Increased sm mass Goblet and mucus gland hyperplasia Angiogenesis Loss of cartilage integrity Inflammation
Leads to Narrowing, BHR, edema
4
Q
Exercise induced asthma
Def and mechanism
A
Def- transient airway obstruction occuring after exercise
Mech- osmotic theory- increase ventilation- waterloss and heat loss- inc osmolarity of ecf- fluid shift from icf- ecf
Increased intracellukar ion concentration
Release of inflammatory mediator
Asthma
5
Q
Vasculr/thermal theory of eia
A
Inc physical activity/cold air Heat loss and cooling of aw Ps nerve stimulation Vagal nerve Bc
6
Q
Tests for eia
Field
Objevtive
A
Field- treadmill and cycle ergometry Objective Direct- metha/histamine Indirect- mannitol/exercise/amp Frast- free running asthma screening test
7
Q
Prevention
A
Warming up Covering nose in cold Exercise in warm/ Humidifier weather Warming down Low Sodium diet
8
Q
Work related asthma presentation
A
Asthma caused by work- occupational
Asthma exacerbated at work
9
Q
Oa latency/no latency
A
Latency- allergic oa- ige dependant Non ige dependant No - non allergic Single exposure- rads Multiple- other than rads
10
Q
Rads/brook syndrome criteria
A
Absence of resp disorder/ asthma Onset of asthma after single exposure High concentration Onset after <24 hrs of exposure Positive bhr Pft may be normal Exclude other
11
Q
Gild standard for diagnosis
A
Bpt
12
Q
How to do pft
A
Atkeast 4 weeks at work and off work
4 times a daily, preferably every 2 hours
