Notable Trials Flashcards
1
Q
What RTOG showed that HPV status as a positive prognostic marker in oropharynx patients?
A
RTOG 0129
2
Q
What was design of RTOG 0129?
A
Phase III randomized trial of 743 patients with stage III/IV oral cavity, oropharynx, hypopharynx, or larynx cancer randomized to two arms
Arm 1 accelerated fractionation (72 Gy in 42 fx in 6 weeks)
Arm 2 standard fractionation (70 Gy in 35 fx)
3
Q
What was the chemo regimen for the two arms from RTOG 0129?
A
Both arms were given with concurrent high dose cisplatin
4
Q
What was the results of the two study arms from RTOG 0129?
A
No difference in overall survival and toxicity between arms
5
Q
What was the result of RTOG 0129 with regard to the HPV association?
A
post hoc analysis found that among oropharynx patients, 3 yrs OS was 82.4% in HPV+ vs 57.1% in HPV-
