Normochromatic Anemias Caused by Hemoglobinopathies

Question 1

Hgb S

Answer 1

Amino acid valine replaces glutamic acid on the 6th position of beta globin chain.

Question 2

Autosomal Co-dominant

Answer 2

inheritance located on chromosome 11. one located on each chromosome. normal or abnormal beta globin chain inherited.

Question 3

Sickling may also be induced by:

Answer 3

Stress, Hypoxia, Acidosis, Dehydration, Fever, and Exposure to cold

Question 4

Severity of symptoms of Sickle cell depends on what?

Answer 4

four haplotypes it Hgb S

Question 5

Hgb C

Answer 5

Amino acid lysine replaces glutamic acid on the 6th position of beta globin chain

Question 6

Hemoglobin C trait

Answer 6

No clinical complications
40% target cells
60% Hgb A and 40% Hgb C

Question 7

Hemoglobin SC disease

Answer 7

target cells, nrbcs, polychromadsia, hjb cells, and few sickled cells will occur

SC crystals “washington monument” “gloved hand”

Question 8

Sickle Cell Anemia Trait vs Disease

Answer 8

Trait: Heterogeneous inheritance of abnormal Hgb

Disease: Homogeneous inheritance of abnormal Hgb

Question 9

Hgb S forms long, thin polymers in areas of low oxygenation in the:

Answer 9

Spleen, Liver, Kidneys, Joints, and Extremities

Question 10

When referring to sickle cell anemia, red blood cells:

Answer 10

have a life span of 10-20 days. chronic hemolysis occurs. hematocrit 20-25%

Question 11

Hemoglobin C disease

Answer 11

Massive spleen.
normochromic/normocytic with a MCHC
Hgb C 80%

Question 12

Hemoglobin E

Answer 12

2nd most common hemoglobin variant worldwide.

lysine substituted for glutamic acid at the 26th position on the b chain of hgb