Normal Skin Flora Flashcards
Characteristics of Peptostreptococcus
Anaerobic Gram +
Coccus
Diseases caused by Peptostreptococcus
URIs
Abscesses formation (tonsillar, abdominal, cerebral)
Necrotizing soft tiss infs
Bone/joint infs
Main Virulence Mechanisms Peptostreptococcus
IgG Fc binding activity
antimicrobial resistance
Polymicrobial synergy establishment
Nationally Notifiable
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Characteristics of Aerococcus
Gram + coccus
Capnophilic
Diseases caused by Aerococcus
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Main Virulence Mechs of Aerococcus
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Characteristics of Propionibacterium acnes
Anaerobic Gram + lipophilic rod (lipid lover) --> puberty
Diseases Caused by Propionibacterium acnes
Acne
Main Virulence Mechs of Propionibacterium acnes
*Glycocalyx biofilm "glue" Glycoside hydrolases B-N-acetylglucosaminidase Lysophospholipase *Triacylglycerol lipase Neuraminidases Several Proteases *Development of inflammation inducing strains
Characteristics of Acinetobacter
Aerobic
Non motile
Pleomorphic
Characteristics of Bacillus
Gram + rod
Aerobic
Form spores
Can be capsulated or not
Virulence mechs of Bacillus
Endospore production
Diseases of Bacillus
Endocarditis Bacteremia Osteomyelititis Meningitis Wound infections Necrotizing Fasciitits
Characterisitics of Staphylococcus aureus
Fac anaerobic Gram + Clumps of coccus Beta-hemolytic Catalase/Coagulase +
Diseases of S. aureus
Staph Scalded Skin Syndrome
Toxic Shock Syndrome
Staphylococcal Food Poisoning (enterotoxin-producing strains)
Virulence mechs of S. aureus
20 diff known adhesions MSCRAMMs: Staph protein A, Fibronectin binding prot A/B (FnbpA, FnbpB), collagen binding protein, clumping factors A and B (Clf)
Exoenzymes: nucleases, proteases, lipases, hyaluronidase, and collagenase
Capsules
What are MSCRAMMs?
microbial surface components recognizing adhesive matrix molecules) –> anchored in the bac cell wall and function to recognize and bind common moities associated with the ECM of host’s cell/blood plasma
Characteristics of Clostridium
Gram + rod
Anaerobic
Spore production
Diseases of Clostridium
Wound infs Clostridial myonecrosis (necrotizing faciitis --> if C. perfringens)
Virulence mechs of Clostridium
Spore production
Stability in deeper tissues (all anearobes!)
Hemolysin production
Collagenase
*Toxins that increase capillary permeability
Capsule
Characteristics of Staphylococcus epidermidis
Gram + clumps of coccus
Coagulase neg
gamma hemolytic
adapted for life on skin
Diseases of S. epidermidis
ICU blood infs
Infs from indwelling medical devices
Virulence mechs of S. epidermidis
Biofilm
*Poly-glutamic acid exopolymer production
MSCRAMMs (fibronectin)
General exoprotease cytolytic enzymes
