Normal Physiology Flashcards

1
Q

pH

A

7.4, range 7.35-7.45

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2
Q

PaC02

A

40mmHg, 35-45

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3
Q

HCO3-

A

24 mEq/L 22-26

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4
Q

PaO2

A
>80mmHg
79-70 - mild
69-60 - moderate
59-50 - severe
<50 - extreme
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5
Q

Oxygen bound to Hb

A

[Hgb] X O2 saturation X binding capacity

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6
Q

What can cause O2 dissociation curve to shift to the left?

A

Increased affinity
decreased temperature, decreased PCO2
increased pH

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7
Q

What can cause O2 dissociation curve to shift to the right?

A

Decreased affinity –> more readily deliver O2 to tissues, e.g. during exercise
Increased temperature, increased PCO2
decreased pH

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8
Q

Haldane Effect

A

Increased loading of CO2 on deoxygenated blood

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9
Q

FiO2

A

0.21

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10
Q

R value

A

.8 to .85

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11
Q

Pbaro

A

760mmHg

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12
Q

How do you calculate PAO2?

A

PAO2 = [(Pbaro - 47mmHg) x FiO2] - (PaCO2/R)

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13
Q

Where does conducting region stop and respiratory begin?

A

After 16th generation

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14
Q

What are the two types of respiratory failure?

A

Type 1: Decreased PaO2

Type 2: Increased PaCO2

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15
Q

What constitues Virchow’s Triad?

A

Hypercoagulability (genetic of acquired); endothelial injury; abnormal blood flow (stasis and turbulence)

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16
Q

Pro-thrombotic

A

Activation of platelets and clotting factors; antifibrinolytic effects

17
Q

Anti-thrombotic

A

Inhibition of platelets, breakdown of ADP, inhibitory effects on coagulation factors, fibrinolysis: cleaves fibrin, degrades thrombi

18
Q

Risk factors for acquired hypercoagulability

A

High Risk of Thrombosis

  • Prolonged bed rest/immobilization.
  • MI, Atrial Fibrillation, prosthetic cardiac valves.
  • Tissue injury(surgery, burn, fracture).
  • Cancer.
19
Q

Pulmonary embollism

A

The most serious form of venous thrombo-embolism occurs when a thrombosis (blood clot) dislodges from a deep vein usually in the lower extremity, and embolizes (travels) through the right side of the heart to the pulmonary circulation