Normal Leukocytes

Question 1

Defined as the production of leukocytes

Answer 1

Leukopoiesis

Question 2

What is the word to describe the protein that transforms an immature cell into a more mature form by undergoing physical and chemical changes induced by specific poietin or growth hormones?

Answer 2

Leukopoietins

Question 3

List the cytokines and hormones that have been identified as having leukopoietin activities:

Answer 3

Interleukins 1 to 19(IL-1 to IL-19
GM-CSF (granulocyte/monocyte - colony stimulating factor)
G-CSF (granulocyte - colony stimulating factor)
M-CSF (macrophage - colony stimulating factor)

Question 4

Production of chemical mediators and antibodies by lymphocytes, plasma cells, granulocytes, monocytes and macrophages, which result in: (2 things)

Answer 4

1) Phagocytosis of foreign antigen that is labelled by antibodies
2) Lysis of foreign and infected body cells by direct killing mechanisms

Question 5

____________ are the primary source for humoral immune responses

Answer 5

B Lymphocytes

Question 6

____________ are responsible for cellular immune responses and are involved in the regulation of antibody reactions by either helping or suppressing the activation of B lymphocytes.

Answer 6

T Lymphocytes

Question 7

_____________ lack B or T cell surface marks and are part of innate immunity, (2 types)

Answer 7

Null cells (third population cells)

Question 8

Antibody-dependent cell mediated lysis?

Answer 8

Killer cells

Question 9

Direct cytotoxic activity?

Answer 9

Natural Killer cells

Question 10

What kind of cell is described in the following sentences?

1) They are resting cells that when stimulated undergo mitosis to produce memory and effortor cells.
2) They recirculate from the blood to the tissues and back to the blood.
3) B and T cells are able to rearrange antigen receptor gene segments to produce a variety of antibodies and surface receptors.
4) T cells and Null cells develop and mature outside of the bone marrow.

Answer 10

How lymphocytes differ from the other leukocytes

Question 11

Stem cells under the influence of _________ __________ differentiate into the ______________, which then matures in several different environments (primary and secondary).

Answer 11

Interleukins (IL1 and IL6)

Lymphoid stem cell (CFU-L)

Question 12

Bone marrow and the thymus produce lymphocytes, promote differentiation and do not require antigenic stimulation. Stem cells from the ________ multiply and differentiate under the influence of cytokines to become __________, while those from the _______ _____________ become ________, each with their own function.

This is called _________ Lymphoid tissue

Answer 12

Thymus
T-lymphs
Bone marrow
B-lymphs

Primary

Question 13

This tissue includes the lymph nodes, spleen, and mucosal associated lymphoid tissues (ex. Peyers patches, tonsils). Reproduction of lymphocytes is predominantly dependent on antigenic stimulation (an active immune response). Secondary lymphoid tissue acts as the main storage areas of already differentiated lymphocytes. This is called ____________ Lymphoid Tissue.

Answer 13

Secondary

Question 14

The stages of lymphocyte development are __________, _______________ and ___________.

Answer 14

Lymphoblast, prolymphocyte, and lymphocyte.

Question 15

Adult normal value for lymphocytes is ___ - ___with approximately ____-____ being T cells and ____-_____ B cells.

Answer 15

20-40 percent
60-80 percent
20-35 percent