Normal Ion concentrations Flashcards
Sodium extracellular
140mM
Sodium intracellular
5-15mM
Bicarbonate intracellular
10-20mM
Bicarbonate extracellular
25mM
Calcium intracellular
0.1 micromolar
Calcium extracellular
2.4mM
K+ extracellular
4mM
K+ intracellular
140mm
Hydrogen ions and pH extracellular
40mM, pH =7.4
Hydrogen ions and pH intracellular
50-100mM, pH-7-7.3
Plasma glucose in fasting
4mM-6mM
Cl- Intracellular
25 mM
Cl- Extracellular
110mM
Plasma osmolarity
~300mOsm/L
Resting membrane potential
-70mv
Ek
-90mv
ENa
+55-60mv
ECl
-65-45mv
Systemic blood pressure
120/80mmHg
Pulmonary blood pressure
20/10mmHg
PaO2
100mmHg, 13.3Kpa
PaCO2
40mmHg, 5.3Kpa
PvCO2
45mmHg
What is the number of WBC in a litre
7 x 10^9
What is percentage of neutrophils
40-70%
What is the percentage of basophils
<1%
What is percentage of monocytes
6%
What is proportion of lymphocytes
20-40%
Diameter of RBC
7.2 micrometer
Normal V/Q ratio
0.8
What is normal heart rate at rest
60-100
What is alveolar ventilation rate
4L /min
What is resting SV
70ml
What is resting cardiac output
5L
What is basal O2 consumption
250ml/min
What is basal CO2 production
200ml/min
What is normal pulse pressure?
40mmHg
Normal CVP
5mmHg
Rough bp in arterioles and capillaries
Arterioles: 50mmHg
Capillaries: 20mmHg
Duration of normal neurone AP and in skeletal muscle
Neurone 1ms
Skeletal muscle 2-5ms
How do you work out clearance of something from blood
Urine conc x urine flow rate/ plasma conc
Range of urine osmolarity
30-1200mOsm
What are volumes of body fluid compartments
Total: 42
Intracellular: 28
Extracelular as plasma: 3, as interstitial fluid: 10, Transcellular fluid: 1
Cells of RBC in one litre
5 x 10^12
What is haematocrit
45%
What is GFR
125ml/min
How do you work out Volume of distribution (Vd)?
Dose/Concentration
How do you work out drug clearance (2 ways)?
(Dose/Interval)/ Total steady state plasma concentration
Elimination constant x Volume of distribution
What is percentage of eosinophils
3%
How to work of total peripheral resistance
(MAP-CVP)/ CO= TPR
How to find VO2/ rate of O2 uptake?
CO ( arterial O2 conc - venous O2 conc)
BP in foot capillaries can reach …
100mmHg
Systolic pressure in right ventricle
25mmHg
What is the respiratory quotient?
CO2 eliminated/O2 consumed
It is a dimensionless number ratio used in a calculation for basal metabolic rate
How to calculate alveolar ventilation rate
(tidal volume - dead space) x breath rate
Anatomical dead space?
150ml
Tidal volume?
500ml
Inspiratory reserve volume?
Max air intake after normal inhalation ~ 3L
Expiratory reserve volume?
Max air exhalation after normal exhalation ~1.5L
Residual volume?
Volume left in lungs after maximum exhalation~1.2 L
Functional residual capacity?
ERV + RV ~2.5-3L
Vital capacity?
After max inhale the max exhale ~5L
Glomerular hydrostatic pressure
45mmHg
Renal plasma flow
625ml/min
Diuresis urine
Up to 20l/day / 20ml/min @ 50mosm
Antidiuresis urine
0.5l/day @ 1200mosm