Normal Anatomy & Physiology Flashcards

CV Anatomy, Intro to Physiology, Organization of Heart, BP Regulation, Cardiac Electrophysiology, E/C Coupling

1
Q

Heart location and position

A

Middle mediastinum with 1/3 mass to the right of midline and with long axis directed from right shoulder to left hip

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2
Q

Thymus location and age at maximum size

A

Superior mediastinum, age 2

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3
Q

CC: persistent left SVC

A

Absence of right SVC, which should be formed by brachiocephalic (innominate) veins joining from both sides.

In persistent L SVC, instead of becoming single large vein, L brachiocephalic vein connects independently to the coronary sinus.

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4
Q

Layers of pericardium

A

Visceral pericardium (epicardium, inner layer) overlies heart and proximal great vessels; parietal pericardium, inferior = adheres to middle of diaphragm, lateral and anterior = contiguous with pleura

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5
Q

Radiographic borders

A

On AP, right = SVC and RA, inferior = RV, left = apex, LV, LAA, superior = pulmonary trunk & left PA

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6
Q

CC: RV hypertrophy (clinical findings)

A

Particularly in children; prominence of left anterior chest, palpable thrust and heave over precordium (because RV is most anterior part of heart)

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7
Q

CC: LV hypertrophy (clinical findings)

A

PMI displaced downwards and outwards

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8
Q

RCA location, branches & supplies ____.

A

RA/RV atrioventricular groove;

1) Acute marginal branch that supplies RV.
2) R posterior “interventricular” descending branch/RPDA sits in posterior interventricular groove & supplies RV, AV node, LV wall.
3) R atrial branch ascends along RA/under RAA, wraps around upper part of atrial septum/SVC and reemerges as the nodal artery to SA node (superior venal caval branch).

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9
Q

LCA location, branches & supplies ____.

A

Runs under pulmonary trunk;

1) L anterior descending (LAD) runs in anterior interventricular groove to apex + ascends into posterior IV groove (first diagonal branch supplies anterior wall & first septal perforator supplies muscular septum).
2) L circumflex (LCX) runs in L atrioventricular groove (obtuse marginal branch supplies LV lateral wall).

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10
Q

Sulcus terminalis

A

Shallow sulcus between SVC and posterior RA, location of SA node

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11
Q

Coronary sinus

A

Venous channel where cardiac veins enter, on posterior L atrioventricular groove -> drains to RA

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12
Q

Apex formed by ____.

A

Entirely by the LV (because posterior and anterior interventricular grooves meet in continuity to RIGHT of the cardiac apex).

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13
Q

Crux

A

Junction point of coronary sulcus and posterior interventricular sulcus, where all 4 chambers intersect

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14
Q

Ascending aorta location and branching

A

Intrapericardial is to the right of pulmonary trunk and covered by RAA, “normally” branches to brachiocephalic (innominate) artery on right, left common carotid, left subclavian.

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15
Q

Pulmonary vein configurations

A

RPV = 2-3, LPV = (1-)2 because may enter LA by common stem

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16
Q

Right atrium

A

Composed of:

1) Posterior, smooth-walled portion from embryonic sinus venosus
2) Trabeculated, thin-walled portion from primitive atrium, on right/free wall starting with lateral aspect of crista terminalis with pectinate muscles

17
Q

Crista terminalis

A

Ridge of muscle that separates smooth and trabeculated portions of RA, corresponds to sulcus terminalis externally (SA node)

18
Q

Eustachian valve

A

Guards anterior border of the IVC ostium (in RA)

19
Q

Thebesian valve

A

If present, guards coronary sinus orifice, which enters RA medial to IVC

20
Q

Fossa ovalis

A

Thin & fibrous, central, ovoid portion of right atrial septum from fetal foramen ovale

21
Q

Foramen ovale closure

A

At birth, LA pressure increases to exceed RA pressure, which functionally closes the valve

20% of adults maintain probe-patent fossa ovalis

22
Q

Acute margin of heart

A

RV

23
Q

Conus arteriosus (infundibulum)

A

From fetal bulbus cordis = musculature in RV that separate cusps of PA from leaflets of tricuspid valve

*Characteristic of RV

24
Q

Left atrium

A

Smooth walled sac with pectinate muscles that are confined to LAA ONLY

25
Q

Membranous septum

A

Small area of ventricular septum between the right and posterior aortic valve cusps that remains thin and membranous (otherwise ventricular septum is muscular)

26
Q

Obtuse margin of heart

A

LV

27
Q

Mitral (bicuspid) valve

A

Actually four cusps: anterior (aortic), posterior (mural), and two commissural cusps

28
Q

Fibrous band

A

Only separation between mitral and aortic valves (aortic-mitral fibrous continuity) because NO CONUS

29
Q

Coronary arteria ostia and path of vessels

A

RCA = right cusp of AV, LCA = left cusp of AV; posterior cusp of AV is “noncoronary cusp”

Run along external surface (epicardial) and penetrate to myocardium (intramural arteries) to provide capillaries

30
Q

R/L dominant split

A

65% to 15%

  • 18% of cases have balanced coronary arterial pattern where both reach the crux
  • apparently in 40% nodal artery is continuation of LCA anterior atrial branch
31
Q

Cardiac muscle cell histology

A

Composed of irregular branched cells bound longitudinally by intercalated disks; have one or two centrally located nuclei and tons of mitochondria

Atrial cells have membrane-bound granules at nuclear poles containing atrial natriuretic factor (ANF), which target kidney natriuresis and diuresis -> most abundant in RA

32
Q

SA node location

A

Surrounds SA nodal artery in the sulcus terminalis (junction of SVC and RAA)

33
Q

AV node location

A

Bordered by 1) septal leaflet of tricuspid, 2) thebesian valve, 3) Eustachian valve

34
Q

Bundle of His & bundle branches

A

AV node is in continuity with AV bundle (Bundle of His), which runs along superior ridge of ventricular septum -> as bundle approaches membranous septum, gives off fibers to left as LBB (cascade down left side) and remaining fibers constitute RBB

35
Q

Purkinje fibers

A

Distal fibers of bundle branches become larger than ordinary cardiac muscle fibers with one or two central nuclei and cytoplasm rich in mitos and glycogen

36
Q

Blood vessels

A

Large elastic arteries branch to muscular arteries

Arteries have pulsatile flow and high pressures, with concentric layers of intima, media, adventitia

Capillaries lack media layer