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March 2020 > noradrenergic > Flashcards

noradrenergic Flashcards

1
Q

substrate for first step of catecholamine synthesis

A

tyrosine

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2
Q

enzyme catalyzing first step of catecholamine synthesis (rate limiting)

A

tyrosine hydroxylase (TH)

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3
Q

formed by hydroxylation of tyrosine meta position

A

DOPA

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4
Q

cofactor for tyrosine hydroxylase

A

BH4

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5
Q

form of iron usable by tyrosine hydroxylase subunits

A

Fe(II)

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6
Q

what DOPA is processed to by aromatic L-amino acid decarboxylase

A

dopamine

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7
Q

Copper-containing enzyme of catecholamine synthesis

A

dopamine beta hydroxylase (DBH)

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8
Q

cofactor of dopamine beta hydroxylase

A

ascorbate (vitamin C)

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9
Q

enzymatic reaction of catecholamine synthesis measured in Kaler Menkes biomarker analysis

A

Dopamine beta hydroxylase (DBH)

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10
Q

only membrane-bound enzyme participating in small molecule neurotransmitter synthesis

A

Dopamine beta hydroxylase (DBH)

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11
Q

converted from Dopamine in the TGN or in secretory vesicles

A

norepinephrine

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12
Q

converts norepinephrine to epinephrine

A

phenylethanolamine n-methyltransferase (PNMT)

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13
Q

metabolizes norepinephrine or epinephrine to metanephrine

A

catechol-O-methyltransferase (COMT)

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14
Q

source of methyl group for PNMT conversion of norepinephrine to epinephrine

A

SAM

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15
Q

COMT metabolites of norepinephrine or epinephrine

A

metanephrine

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16
Q

class of enzymes metabolizing dopamine and norepinephrine to DOPAC and DHPG

A

Mono amine oxidases (MAOs)

17
Q

MAO metabolite of dopamine

A

DOPAC

18
Q

MAO metabolite of norepinephrine

A

DHPG

19
Q

catechol metabolite which builds up without copper cofactor in the synthesis pathway

A

DOPAC

20
Q

catechol metabolite which is reduced in menkes patients

A

DHPG

21
Q

technique used to analyze catecholamine metabolites in newborn screens

A

HPLC

22
Q

adsorbs catechols in alkaline and desorbs them in acidic environments

A

alumina

23
Q

nucleus in pons which is the principal norepinephrine synthesis site in brain

A

Locus Coeruleus

24
Q

location of pons with respect to brain cavity

A

floor of 4th ventricle

March 2020 (2 decks)

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