Non small cell lung cancer

Question 1

What are the 4 types of non small cell cancer

Answer 1

1. Squamous cell cancer
2. Adenocarcinoma
3. Large cell carcinoma
4. Alveolar cell carcinoma

Question 2

What is the most common type of non small cell cancer?

Answer 2

1. Squamous cell carcinoma (35%)

Question 3

What is the histology of squamous cell lung cancer?

Answer 3

1. Squamous cell differentiation

1. Keratinisation

Question 4

What is the pathology of squamous cell lung cancer?

Answer 4

1. Centrally located

2. metastasise late

Question 5

What is the paraneoplastic syndrome associated with squamous cell lung cancer?

Answer 5

1. High parathyroid hormone - hypercalcaemia

2. HPOA - hypertrophic pulmonary osteoarthropathy
digital clubbing + joint pain

Question 6

What is the epidemiology of Adenocarcinoma?

Answer 6

most common type of cancer in non smokers

Question 7

What is the histology of adenocarcinoma?

Answer 7

1. Glandular differentation

2. Mucin formation

Question 8

What is the pathology of adenocarcinoma?

Answer 8

1. Typically peripheral

2. Mets fast (80% present with mets)

Question 9

What is the paraneoplastic syndrome associated with adenocarcinoma?

Answer 9

Gynocomastia

Question 10

What is the histology of large cell cancer?

Answer 10

Largely poorly differentiated cells

Question 11

What is the pathology of ‘Large cell cancinoma’?

Answer 11

1. Peripheral / centrally located

Question 12

What is the paraneoplastic syndrome associated with Large cell lung cancer?

Answer 12

Secrete Beta HCG

Question 13

What are the features of ‘Alveolar cell carcinoma’?

Answer 13

1. not related to smoking

2, Causes excessive sputum