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Pharmacology > Non-opioids > Flashcards

Non-opioids Flashcards

1
Q

COX inhibitors MOA

A

inhibits cyclooxygenase (prevent PG synthesis) - > PG1 and Arachidonic acid

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2
Q

COX 1

A

platelet functions -> decreased risk of thrombosis

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3
Q

COX 2

A 
inflammation pathway (bigger receptor site), "triggerable pathway"
- no effect on platelets or gut

COX2 inhibitors –> increased risk of heart attack

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4
Q

Aspirin

A

irreversibly binds to COX 1 (acetylation)

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5
Q

Absorption of COX

A

all well absorbed, peak around 2-3 hrs

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6
Q

Distribution of COX

A

highly protein bound drugs, high lipid solubility

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7
Q

Biotransformation

A

hepatic transformation

APAP has the toxic metabolite

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8
Q

NSAIDs ceiling effect

A

analgesia has a ceiling effect with NSAIDs, but the other effects (renal, GI, platelets) do not

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Pharmacology (11 decks)

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