Non Insulin Flashcards
Acarbose - Dosages
50 mg, 100 mg tablets
Acarbose - Pharmacology Class
α-Glucosidase inhibitor
Acarbose - Maximum Dose
300 mg/day in divided doses for patients over 60 kg, 150 mg/day for patients under 60 kg
Acarbose - Adverse Effects
Gastrointestinal issues (flatulence, abdominal pain, diarrhea), possible transient increase in hepatic enzymes, rarely hypoglycemia.
Acarbose - Administration Notes
Take with the first bite of each meal. Titrate dose slowly to minimize side effects. Not recommended for patients with severe renal impairment (serum creatinine >2 mg/dL). Use with caution in patients with liver disease or digestive issues.
Miglitol - Pharmacology Class
α-Glucosidase inhibitor
Metformin - Brand Names
Glucophage, APO-Metformin, Metforbax, Rehamet, Metfortex, Metfobet
Metformin - Dosages
500 mg, 750 mg, 1000 mg tablets, also available in extended release forms like Glucophage XR
Metformin - Pharmacology Class
Biguanide
Metformin - Maximum Dose
2550 mg per day
Metformin - Adverse Effects
Gastrointestinal issues (nausea, diarrhea, metallic taste), Vitamin B12 deficiency, rarely lactic acidosis, can cause weight loss or be weight neutral.
Metformin - Administration Notes
Take with food to minimize gastrointestinal side effects. Start with low doses and gradually increase. Avoid in patients with severe kidney disease (eGFR < 60 mL/min), liver disease, or alcohol abuse. Hold medication 48 hours before and after contrast imaging.
Gliclazide - Brand Names
Diamicron, Diabezid
Gliclazide - Dosages
30 mg, 60 mg, 80 mg tablets
Gliclazide - Pharmacology Class
Sulfonylurea
Gliclazide - Maximum Dose
320 mg
Gliclazide - Adverse Effects
Hypoglycemia, weight gain, GI issues. Hypersensitivity, potential for liver and blood problems.
Gliclazide - Administration Notes
Take with food. Use with caution in the elderly and those with kidney or liver disease.
Glibenclamide/Glyburide - Brand Names
Daonil, Glibutex
Glibenclamide/Glyburide - Dosages
1.25, 2.5 and 5mg
Glibenclamide/Glyburide - Pharmacology Class
Sulfonylurea
Glibenclamide/Glyburide - Maximum Dose
20 mg
Glibenclamide/Glyburide - Adverse Effects
Hypoglycemia, weight gain.
Glibenclamide/Glyburide - Administration Notes
Take with food. Use with caution in the elderly due to risk of hypoglycemia.
Glipizide - Pharmacology Class
Sulfonylurea
Glipizide - Maximum Dose
40 mg
Glipizide - Adverse Effects
Hypoglycemia, weight gain.
Glipizide - Administration Notes
Short-acting, may be preferred in elderly patients.
Glimepiride - Brand Name
Amaryl
Glimepiride - Dosages
1,2,3,4mg tabs
Glimepiride - Pharmacology Class
Sulfonylurea
Glimepiride - Maximum Dose
8 mg
Glimepiride - Adverse Effects
Hypoglycemia, weight gain.
Glimepiride - Administration Notes
Take with first meal of the day.
Repaglinide - Dosages
0.5 mg, 1 mg, 2 mg tablets