Non-inflammatory MS Flashcards
Joint that allows free range of motion?
Synovial Joint “free movable didrthroses”
A synovial joint is between which two structures?
Between bones formed by enchondral ossification
What is a synovial membrane?
A membrane that surrounds the joint and produces synovial fluid. Bathes and protects articular cartilage
What is Synarthroses?
When there is not joint space Fibrous synarthroses and Cartilaginous Synarthroses
What type of synarthroses forms at the cranial sutures and bonds between root of teeth and jaw?
Fibrous synarthroses
Define Cartilaginous synarthroses?
symphyses (manubriosternalis and pubic)
Synovial membrane?
forms boundary of joint space and is firmly anchored to the capsule Contains a smooth contour except has numerous villous folds near osseous insertion
What does the synovial lines lack?
a basement membrane
What overlies the vascularized loose connective tissue storm and allows for quick exchange between blood and synovial fluid?
Synovial membrane
Synoviocytes
lacks keratin not epithelium 1-4 cells deep over synovial membrane Fibroblast like cells also associated with macrophages Not present over articular cartilage P
What produces proteins and hyaluronic acid in the synovial joint?
Synoviocytes
What is the content of hyaline cartilage
Type 2 collage Water - 70% Proteoglycans 8% Chondrocytes
What lacks a blood supply, no lymphatics, has no innervation and cushions long bone?
Hyaline cartilage
Which part of the hyaline cartilage is the thickest?
Thickest at periphery of concave surfaces and in central portions of convex surfaces
I secrete inactive enzymes and enrich matrix with enzyme inhibitors. Who am I?
Chondrocyte
This structure is composed of type 1 collagen and is between muscle and bone
Tendon
Ligament are between bones. What type of collagen are they made of?
Type 1 collagen
How does one get septic arthritis?
Bacteria seed the joint during bacteremia or direct spread
Contiguous spread of septic arthritis from epiphyseal osteomyelitis typically occurs in which population?
Neonates/infants/young children This is down by hematogenous spread
What pathogens cause septic arthritis?
Staphlococcus > streptococcus > haemophilus influenza, GNB (E. coli, Salmonella, and Psuedomonas)
A staph aureus septic arthritis infection is typically seen in which population?
Older children and adults
15-25 mainly get septic arthritis from which pathogen?
Neisseria gonorrhea
Patient comes in to review their x-ray from their last appointment. Ashe was diagnosed with Septic arthritis. What was seen in the radiology report?
lytic lesions that may have periosteal elevations
What are the systemic symptoms of septic arthritis?
fever, leukocytosis, increased ESR, and increased CRP
This condition typically affects a single knee (monoarthritis), with the knee joint being most common?
Septic arthritis also affects the hip > shoulder, elbow, wrist vs multiple joints in 22%
T/F Septic arthritis pain gets better when moving?
Severe pain with movement along with swelling) “Warm to touch” Pt will also experience fatigue and generalized weakness
What is Arthrocentesis?
sticking a needle into the joint fluid and aspirating content out
This obtained for evaluation
Analysis of WBC, viscocity
A culture is also done on the fluid
What is the most likely diagnosis?
What is the workup on this patient?
Septic Arthritis
Labs - CBC, ESR, CRP
X-ray - to identify within joint and/or in surrounding tissues
Arthrocentesis
Other imaging: nuclear scans, MRI, CT scan are the most common
Synovial fluid joint with PMNs containg organisms.
What stain is being used?
Wright Giemsa Stain
Neutrophils and organism look blue