non hormonal signalling Flashcards
what does NO stimulate
Activates guanylyl cyclase cGMP
where fo non hormonal chemical signals elicit response
nearby target cells
1. cytokins (TNF-a-ILs) and GF (IGF)
2. gases- NO and CO
3. lipids- prostaglandins
how does L-arginine produce NO
with oxygen and nitric oxide synthase
release NO and citrulline
NO acts as what
a neurotransmitter and neuromodulator in the brain
NO is produced by
endothelial cells
NO diffeuse into what cells to cause what
smooth muscle cells to cause vasodillation
CO activates what and targets what cells
Activates guanylyl cyclase cGMP
Targets smooth muscle and neural tissue
prostaglandins first identified in
semen and believed to orifinate from prostate glands
locally acting chemical messangers
prostaglanding
prostaglandin structure
20-C FA derivatives with 5-C ring
prostaglandins are produced by what tissues and from what
all tissues from arachidonic acid
arachidonic acid is a what
constituent of FA of phospholipids)
upon stimulation arachidonic acid splits from
plasma membrane by memvrane bound enxyme
cobnverted to appropriate PG
prostaglandins following actions
Following actions, inactivated by local enzyme before reaching blood
PG belong to 1 of 3 groups naemely
PGA, PGE, PGF (structural variation of 5-C ring)
