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Alireza Shokat - Pathophysiology > Non-Hodgkin Lymphoma (NHL) > Flashcards

Non-Hodgkin Lymphoma (NHL) Flashcards

1
Q

Chronic lymphocytic leukemia (CLL)

A
  • Most common leukemia (not sure)
  • Overexpression of Bcl-2
  • Neoplasm of mature B cells, expressing CD19, CD20, CD23, and Ig heavy and light chains
  • Only CLL and mantle cell lymphoma express CD5
  • Having CD38+ CLL is considered a poor diagnostic marker
  • Eventually (not sure!) will transform to ALL (wrong?) or DLBL (Richter’s syndrome)
  • Rai staging and Binet staging
  • Incurable
  • Chemotherapy: rituximab (anti-CD20) + cyclophosphamide (CP)
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2
Q

Follicular lymphoma

A
  • B cell origin
  • Indolent
  • Most common indolent lymphoma in adults
  • t(14,18) ► Bcl-2 overexpression ► inhibition of apoptosis
  • 50% progress to DLBL
  • Incurable
  • Rituximab
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3
Q

Hairy cell leukemia

A
  • B cell origin
  • Indolent
  • Mainly in older males
  • BRAF mutations
  • Massive splenomegaly and pancytopenia
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4
Q

Marginal zone B cell lymphoma

A
  • B cell origin
  • Indolent
  • E.g. gastric MALT lymphoma
    • Associated with t(11,18) and H. pylori infection
  • Most common in adults
  • Associated with autoimmune diseases
    • Sjogren syndrome
    • Hashimoto thyroiditis
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5
Q

Waldenstrom macroglobulinemia

A
  • B cell origin
  • Indolent
  • IgM antibodies
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6
Q

Small cell lymphocytic lymphoma (SLL)

A
  • B cell origin
  • Indolent
  • What’s the connection with CLL?
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7
Q

Diffuse large B cell lymphoma (DLBL)

A
  • B cell origin
  • Aggressive
  • Most common NHL in adults
  • Caused by mutations of Bcl-2, Bcl-6, P53
  • Primary CNS lymphoma
    • Associated with EBV and AIDS
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8
Q

Mantle cell lymphoma

A
  • B cell origin
  • Aggressive
  • Most common in adult men
  • t(11,14) ► overexpressin of cyclin D1 ► promotes proliferation
  • CD5+
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9
Q

Burkitt lymphoma

A
  • B cell origin
  • Aggressive
  • Associated with EBV and AIDS
  • Most common in children
  • t(8,14) ► overactivation of c-myc proto-oncogene
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10
Q

Acute lymphoblastic leukemia (ALL) - precursor B cell lymphoblastic lymphoma

A
  • B cell origin
  • Aggressive
  • Most common in adolescents and young adults
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11
Q

Mycosis fungoides

A
  • T cell origin
  • Indolent
  • Proliferation fo CD4+ T cells
  • May lead to Sézary syndrome (aggressive)
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12
Q

Adult T cell lymphoma

A
  • T cell origin
  • Aggressive
  • Proliferation fo CD4+ T cells
  • Occurs exclusively in adults
  • Caused by HTLV (human T cell lymphotropic virus)
  • Hypercalcemia
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13
Q

Acute lymphoblastic leukemia (ALL) - precursor T cell lymphoblastic lymphoma

A
  • T cell origin
  • Aggressive
  • Predominantly adolescents and young adults
  • SVC syndrome
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14
Q

t(14,18)

A

Follicular lymphoma

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15
Q

t(11,18)

A

Gastric MALT lymphoma

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16
Q

t(11,14)

A

Mantle cell lymphoma

17
Q

t(8,14)

A

Burkitt lymphoma

Alireza Shokat - Pathophysiology (3 decks)

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