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Anatomic Pathology > Non-Hodgkin Lymphoma > Flashcards

Non-Hodgkin Lymphoma Flashcards

1
Q

The earliest IHC marker for B-lineage differentiation.

A

CD19

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2
Q

Acquired late in pre-B-cell stage of maturation; lost at the plasma cell stage.

A

CD20

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3
Q

Strongly positive: half of lymphoblastic lymphoma/leukemia; all mature B-cell lymphomas; Reedsternberg cells in 1/4 cases of HL

A

CD20: cytoplasmic staining

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4
Q

IHC marker found in follicular dendritic cells and some B lymphocytes; helps identify the hyperplastic islands of dendritic cells in angioimmunoblastic T-cell lymphoma.

A

CD21

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5
Q

IHC marker strongly expressed in hairy cell leukemia.

A

CD22

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6
Q

IHC marker that is most useful in distinguishing B-cell CLL/SLL from other entities and remains present in CLL/SLL that has undergone large cell transformation.

A

CD23

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7
Q

Expressed in nearly all of the assayed precursor B-cell lymphoblastic lymphoma/leukemias, with no T-cell staining. Also positive in mature B-cell lymphomas.

A

CD79a

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8
Q

Strongly stains the cytoplasm of most hairy cell leukemias, marginal zone lymphomas, and large cell lymphomas

A

DBA.44

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9
Q

Normal lymph node: CD79a positive as marker for early B-cell antigen

A

Mantle zone
Most germinal centers
Scattered interfollicular zone

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10
Q

Normal lymph node: CD2 positive areas as marker for early T-cell antigen.

A

Most interfollicular lymphocytes as well as scattered in light zone of germinal center

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11
Q

IHC marker for early T-cell antigen in a normal lymph node.

A

CD2

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12
Q

Positive with most T-cell lymphomas except anaplastic large cell lymphomas and NK leukemias/lymphomas. Very specific for T-cell derivation.

A

CD3 (cell membrane)

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13
Q

It interacts with HLA class II during antigen recognition, and defines a helper-inducer subset of T cells. Expressed in most mature T-cell lymphomas.

A

CD4

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14
Q

Detectable on the surface of most thymocytes and immature peripheral T cells and in a small subset of circulating B cells. Primarily used in the detection of B cell CLL/SLL and mantle cell lymphoma.

A

CD5

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15
Q

It has the distinction of being the most frequently lost T-subset marker in malignancies, particularly on mycosis fungiodes.

A

CD7

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16
Q

Also present on non-T-cell malignancies, including NK tumors and AML

A

CD7

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17
Q

This antigen defines the suppressor/cytotoxic T-cell subset.

18
Q

t(2;5)

A

Anaplastic large cell lymphoma

19
Q

Expression is limited to ALCL and rare DLBCL

A

ALK (anaplastic lymphoma kinase): cytoplasm and nucleus

Also CD30+, EMA+, CD15-

20
Q

t(11;14)

A

Mantle cell lymphoma

21
Q

Hallmark of mantle cell lymphomas. Weaker signal in hairy cell leukemia and plasmacytoma.

A

Cyclin D1 (aka BCL-1 and PRAD 1): nuclear

22
Q

t(14;18)

A

Follicular lymphoma

23
Q

Found in app 3/4 of cases of follicular lymphoma.

A

BCL-2: stains malignant follicles

Reversed pattern in lymph nodes exhibiting follicular hyperplasia

24
Q

Normally present in the cytoplasm of follicular mantle B lymphocytes, occasional germinal center cells, and many T lymphocytes.

25
Q

Expressed normally in germinal center lymphocytes.

26
Q

Expressed in a variety of B-cell neoplasms. Also detected in L&H variants of nodular lymphocyte predominant Hodgkin disease.

27
Q

Ag associated with beta 2 macroglobulin. Found in a subset of precursor T-lymphoblastic lymphoma/leukemia.

28
Q

Almost always present on the surface of precursor B lymphoblastic and Burkitt’s lymphomas, many FL and some DLBCL along with MM

A

CD10 (CALLA)

29
Q

X hapten or Lewis X antigen

30
Q

Marker for RS cells of classical HL. Also used to stain adenocarcinomas.

A

CD15: membranous with a paranuclear dot-like Golgi localization

31
Q

IL-2 receptor. Expressed on hairy cell leukemia and adult T-cell leukemia/lymphoma.

32
Q

Ki-67 index (nuclear staining)

A

Burkitt’s lymphoma

33
Q

BCL-2 positivity in enlarged follicles

A

Follicular lymphoma

34
Q

BCL-2 positivity around follicles

A

Reactive hyperplasia

35
Q

Almost always present in the nucleus of lymphoblastic lymphoma cells

36
Q

CD20+

BCL-2+

A

Mantle cell lymphoma
Follicular lymphoma
Some marginal zone lymphoma

37
Q

B-CLL/SLL vs Mantle cell lymphoma

A

B-CLL/SLL:
CD23 (+)
Cyclin D1 (-)

Mantle cell lymphoma:
CD23 (-)
Cyclin D1 (+)

38
Q

B-CLL/SLL vs Follicular lymphoma

A

B-CLL/SLL:
CD10 (-)
CD5/CD43 (+)

39
Q

Predicts poor outcome in B-CLL

40
Q

Mature B lymphocytes vs plasma cells

A

Mature B lymphocytes:
CD45RB (+)
CD20 (+)

41
Q

Sensitive for follicular lymphoma but not specific

42
Q

CD30 expressivity in a Golgi and cell membrane pattern

Anatomic Pathology (3 decks)

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