Non-coding DNA essay Flashcards
1
Q
2 ways of determining genome functionality
A
sequence conservation
biological activity (e.g. ENCODE)
2
Q
example of an epigenetic use of a TE
A
regulation of a stress response gene in Arabadopsis, as it helps produce regulatory siRNAs which reduce the stress response. UBP1b
3
Q
example of a microsatellite which appears functional
A
microsatellite in regulatory region of HO-1, seems to modulate cancer risk by preventing downreg. of this antioxidant gene
4
Q
pseudogene which may have functionality
A
PTENP1, binds to miRNAs and prevents them from acting- again helps regulate cancer risk by stopping inactivation of tumour suppressors