Non Bata Lactam : Cell Wall Synthesis Inhibitor

Question 1

antibiotics cannot be used for pregant pt:

Answer 1

1. Quinolones
2. Clindamycin
3. Metronidazole
4. Chloramphenical
5. Aminoglycoside
6. Tetracyclines

Question 2

Vancomycin

Answer 2

1. Is a glycopeptide, non beta lactam
2. Is a cell wall synthesis inhibitor
3. Inhibit the “transglycosylase”
4. Do not work well for “formed” bacteria ,
5. Mainly works on actively deviding gram +ve bacteria
6. Works for MRSA, CD infection
7. Vanco time dependent killing and AUC/MIC >400,
8. Tough level 15 to 20mg/l
9. S.e. red man syndrome, derm rashes, heam (neutropenia amd thrombocytopenia), renal and ototxicity

Question 3

Drugs can penetrate CSF:

Answer 3

1. Vancomycin ( penetrates inflammed meninges
2. Monobactams (Aztreonam) (some penetrates inflammed meninges)
3. Cefuroxime, 3rd, 4th, 5th cephalosporins
4. Carbapenam ( meropenem, imipenem)