Non-Barbiturates

Question 1

name three non-barbiturate induction drugs

1.

2.

3.

Answer 1

1. propofol
2. etomidate
3. ketamine

Question 2

chemical name: propofol

Answer 2

2,6 diisopropylphenol

Question 3

physical properties: propofol

1.

2.

Answer 3

1. oil at room temperature
2. insoluble in aqueous solution

Question 4

solution components of propofol

most prevalent component

Answer 4

soybean oil

Question 5

solution components of propofol

inhibits microbial growth for up to 12hr

Answer 5

0.005% disodium edetate

Question 6

solution components of propofol

anaphylactic component

Answer 6

1.2% purified eff phosphatide

Question 7

solution components of propofol

agent that causes venous irritaiton/burning

Answer 7

2.25% glycerol

Question 8

mechanism of action: propofol

Answer 8

decreased dissociation of GABA from cells receptors

increased inhibitory side of CNS

Question 9

dose: propofol

Answer 9

1-2.5mg/kg IV

Question 10

propofol

1. onset
2. peak effect
3. duration of action
4. recovery

Answer 10

1. onset: 30sec
2. peak effect: 90-100sec
3. duration of action: 5-10min (dose dependent)
4. recovery: distribution half life is 2-8min

context sensitive half time of prolonged infusions less than 40min

Question 11

vvvvvvvvpharmacokinetics: propofol