Non Alcoholic Fatty Liver Disease

Question 1

What is N.A.F.L.D,

Answer 1

It’s a spectrum of diseases
From least severe to most severe 
Steatosis 
Steatohepatitis
Fibrosis 
Cirrhosis

Question 2

Etiopathogenesis of non alcoholic fatty liver disease

Answer 2

Due to fat deposition in the liver
Unrelated to alcohol or viruses 
It affects individuals with metabolic syndrome that is ;
Obesity 
Hypertension 
Diabetes 
 Hypertriglyceridemia 
Hyperlipidemia 

Insulin resistance results in insulin receptors to be less responsive , in result the liver goes into increase fat storage and decrease fatty acid production that means decrease of lipids release into the blood stream in the form of lipoproteins
And increase of fatty acids uptake in blood called steartosis causing fat droplets to form around hepatocytes, causing nucleus to appear at the edge of cell
Overtime the liver is vulnerable to degradation
Lipid membrane damaged causing cell death causing stearrthoe hepatitis
Steatohepatitis can cause stellate cells to lay down fibrotic tissue that is fibrosis
Overall architecture of the liver changes causing cirrhosis

Question 3

Clinical picture of non alcoholic fatty liver disease

Answer 3

Even at advanced stages the patient may be asymptomatic

Symptoms include ;
Fatigue 
Malaise
Pain
Jaundice

Question 4

Diagnosis of non alcoholic fatty liver disease

Answer 4

Hepatomegaly on physical exam
Ascites

Increase ASAT, ALAT in biochem
US abdominal
Ct MRI
Liver biopsy - a liver with more than 5% fat content is considered abnormal

Question 5

Treatment of non alcoholic fatty liver disease

Answer 5

Steartosis and steatohepatitis are reversible with a healthy diet, active lifestyle,meds that control blood glucose