Nomenclature And Apolipoproteins Flashcards
What is a lipoprotein?
Biochemical assembly of protein and lipids
Lipoprotein has a hydrophobic core made up primarily of ___ and ____
Cholesterol ester and triacylglycerol
Hydrophobic core is surrounded by a hydrophilic membrane consisting of ____, ___ and ___
Phospholipids, cholesterol and apolipoproteins
What are apolipoproteins ?
Protein component of plasma lipoprotein
Chylomicrons contain Apo __, __, __, __, __ and __
Apo B-48, A-1, A-11, A-V1, A-V, C-11 and C-111
Where are Chylomicrons made?
The intestine
___ is removed from Chylomicrons to form Chylomicrons remnants?
Triacylglycerol
VLDL is produced by the ?
Liver
VLDL contains Apo ?
B-100, C-1, C-11, C-111 and Apo -E
__ is the core structural protein of VLDL
Apo B-100
The size of VLDL depends on the amount of ___ while the size of Chylomicrons depends on the amount of. ___
Triacylglycerol, fat
IDL Is formed from the removal of Triacylglycerol by ___ and ___ tissue
Muscle and adipose
IDL contains Apo __ and ___
B-100 and Apo -E
Chylomicrons remnant and VLDL remnants (IDL) are pro-arthenogenic. True or false ?
True
Predominant apolipoprotein of LDL is ?
Apo B-100
What is the importance of HDL ?
It plays a role in the reverse transport of cholesterol from peripheral tissues to the liver
- it is anti- Arthenogenic
HDL contains Apo ___________
A-1, A-11, C-1, C-11, C-111, A-1V
__ is the core protein of HDL
Apo A-1
All apolipoprotein A subclasses are synthesized where? Except ___ which is synthesized where ?
The liver
- Apo A-1V synthesized In the small intestine
______ enzyme converts cholesterol to cholesterol ester and it is activated by ?
- lesithine cholesterol Acyl transferase
activated by Apo A-1
Apo B-48 is synthesized where ?
Small intestine ( it is exclusively found in the Chylomicrons)
___ is the longest known protein to humans?
Apo B-100
___ apolipoprotein activates lipoprotein lipase
Apo c-11
*apo c-111 inhibits it
