NOACs Flashcards
1
Q
Target of Warfarin
A
Vitami K epoxide reductase
2
Q
Target of Dabigatran
A
Thrombin
3
Q
Target of Rivaroxaban
A
Factor Xa
4
Q
Target of Apixaban
A
Factor Xa
5
Q
Target of Edoxaban
A
Factor Xa
6
Q
Oral bioavailability of NOACs and warfarin
A
Dabigatran 6-7% Rivaroxaban 80% Apixaban 50% Edoxaban 62% warfarin 99%
7
Q
Time for Peak Concentration NOACs and warfarin
A
Warfarin 48-72 hrs Dabigatran 2-3 hrs Rivaroxaban 2.5-4 hrs Apixaban 3-4 hrs Edoxaban 1-2 hrs
8
Q
Metabolism or elimination of NOACs and warfarin
A
Warfarin via Cytochrome P450
Dabigatran Via P-Glucuprotein transporter/ 80% renal excretion
Rivaroxaban via cytochrome P450. via P Glucoprotein transporter / 33% renal excretion
Apixaban via cytochrome P450 via P glucoprotein transporter/ 27% renal excretion
Edoxaban via cytochrome P450 / via P Glucoprotein transporter/ 50% renal excretion
9
Q
Dosing Dabigatran
A
150mg BID
10
Q
Dosing Rivaroxaban
A
20mg once daily
11
Q
Dosing Apixaban
A
5 mg BID
