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MSK II Exam I > NMJ Drugs > Flashcards

NMJ Drugs Flashcards

1
Q

Atracurium

A

Nondepolarizing NMJ blocker- Isoquinoline derivative

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2
Q

Cisatracurium

A

Nondepolarizing NMJ blocker- Isoquinoline derivative

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3
Q

Doxacurium

A

Nondepolarizing NMJ blocker- Isoquinoline derivative

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4
Q

Metocurine

A

Nondepolarizing NMJ blocker- Isoquinoline derivative

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5
Q

Mivacurium

A

Nondepolarizing NMJ blocker- Isoquinoline derivative

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6
Q

Tubocurarine

A

Nondepolarizing NMJ blocker- Isoquinoline derivative

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7
Q

Pancuronium

A

Nondepolarizing NMJ blocker- steroid derivative

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8
Q

Pipecuronium

A

Nondepolarizing NMJ blocker- steroid derivative

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9
Q

Rocuronium

A

Nondepolarizing NMJ blocker- steroid derivative

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10
Q

Vecuronium

A

Nondepolarizing NMJ blocker- steroid derivative

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11
Q

Succinylcholine

A

Depolarizing NMJ blocker
AE: hyperkalemia, increased intraoccular pressure
CI: malignant hyperthermia, not with kids <12 (cardiac arrest risk if underlying skeletal muscle myopathy)

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12
Q

Dantrolene

A

Muscle relaxant(spasmolytic) - inhibits ryanodine receptors(malignant hyperthermia)

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13
Q

Botulinum toxin

A

Muscle relaxant(spasmolytic) - cleaves SNARE complex

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14
Q

Ambenonium

A

AChE inhibitor

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15
Q

Donepezile

A

AChE inhibitor

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16
Q

Echothiophate*

A

AChE inhibitor

17
Q

Edrophonium*

A

AChE inhibitor

18
Q

Galantamine

A

AChE inhibitor

19
Q

Neostigmine*

A

AChE inhibitor

20
Q

Physostigmine*

A

AChE inhibitor

21
Q

Pyridostigmine*

A

AChE inhibitor

22
Q

Rivastigmine

A

AChE inhibitor

23
Q

Tacrine

A

AChE inhibitor

24
Q

Atropine*

A

Antimuscarinic compunds

25
Q

nondepolarizing NM blocking agents

A

distribute fast, eliminate slow
poor solubility
competitive antagonists at nAChR

26
Q

how to reverse nondepolarizing NM blocking agents

A

add acetylcholine or succinylcholine
or cholinesterase inhibitors
neostigmine/pyridostigmine - AChE inhibitors that increse release

27
Q

What do you give with AChE inhibitors?

A

Anticholinergic agents - atropine glycopyrrolate

prevent bradycardia, bronchoconstriction

28
Q

AE of nondepolarizing NM blocking agents

A

can cause histamine release - wheals, bronchospasm, hypotension, bronchial/salivary secretion
-less with steroids
CV effects of hypotension and tachycardia

29
Q

What drugs use for rapid sequence intubation

A

succynilcholine, rocuronium, vecuronium

30
Q

What drugs for surgical muscle relaxation

A

pancuronium, atracurium, cisatracurium

31
Q

Drugs for hepatic/renal insufficiency?

A

atracurium, cisatracurium

MSK II Exam I (5 decks)

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