Nitroglycerin (Nitrostat)

Question 1

Nitroglycerin (Nitrostat) indications

Answer 1

• Ischemic chest pain
• Acute hypertension
• Acute decompensated heart failure

Question 2

Nitroglycerin (Nitrostat) contraindications

Answer 2

• Hypotension
• Hypovolemia
• Intracranial bleeding
• Use of phosphodiesterase inhibitors within the past 48hrs
• caution with (R) ventricular infarction or severe aortic stenosis

Question 3

Nitroglycerin (Nitrostat) drug class

Answer 3

Vasodilator

Question 4

Nitroglycerin (Nitrostat) sublingual dose for acute coronary syndrome

Answer 4

0.4mg tablet (or spray)
Repeat every 3-5 min
Max: 3x in 15 min

Question 5

Nitroglycerin (Nitrostat) dose for acute decompensated heart failure/ flash pulmonary edema

Answer 5

0.4-0.8 SL (1-2 tabs/ sprays) every 3-5 mins

Question 6

Nitroglycerin (Nitrostat) kinetics

Answer 6

Onset: 1-3 min (SL)
Immediately (IV)

Duration: 20-30 min (SL)
3-5 min (IV)

Question 7

Nitroglycerin (Nitrostat) has greater venous or arterial effects?

Answer 7

Greater venous effects (dilates the veins)

Question 8

Nitroglycerin (Nitrostat) reduces preloaded - leading to

Answer 8

• decrease in myocardial wall tension

- less oxygen consumption

Question 9

Nitroglycerin (Nitrostat) dilates which arteries

Answer 9

Coronary

Question 10

NTG (CO) is though to stimulate production of?

• CAMP
• MACHRS
• CGMP

Answer 10

cGMP